Ageusia associated to treatment with amitriptyline and terbinafine

V. P. Jerath, Megha Sood


Ageusia is a rare condition characterized by loss of taste functions of the tongue.
A large number of conditions may be responsible for causing ageusia. Adverse
effects of drug therapy are the most common cause for the loss of taste. Ageusia
can have a significant effect on the quality of life of patients and can lead to loss
of appetite, weight, and may require discontinuation of drug administration in
already compromised patients. We present two cases of ageusia one associated with
amitriptyline in a patient with endogenous depression and the other with terbinafine
in patient with tinea unguium.


Ageusia, Amitriptyline, Terbinafine

Full Text:



Mann NM. Management of smell and taste problems. Cleve Clin J Med. 2002;69(4):329-36.

Ksouda K, Affes H, Hammami B, Sahnoun Z, Atheymen R, Hammami S, et al. Ageusia as a side effect of clopidogrel treatment. Indian J Pharmacol. 2011;43(3):350-1.

González Vallés V, Calvo Catalá J, Campos Fernández C, Rueda Cid A. Ageusia associated to treatment with pregabalin. Reumatol Clin. 2010;6(1):71.

Deguchi K, Furuta S, Imakiire T, Ohyama M. Case of ageusia from a variety of causes. J Laryngol Otol. 1996;110(6):598-601.

Sinha R, Sharma P, Kumar P, Kuchhal V. Terbinafine induced taste impairment-report of two cases. J Pak Assoc Dermatol. 2012;22 (4):363-5.

Golka K, Roth E, Huber J, Schmitt K. Reversible ageusia as an effect of clopidogrel treatment. Lancet. 2000;355(9202):465-6.

Amitriptyline drug information. Available at Accessed 9 January 2014.

Henkin RI. Drug-induced taste and smell disorders. Incidence, mechanisms and management related primarily to treatment of sensory receptor dysfunction. Drug Saf. 1994;11(5):318-77.

DeBattista C. Antidepressant agents. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th Edition, Chapter New York: McGraw Hill; 2009: 509-30.