DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20175686

Evaluation of antidiabetic activity of fruit of Coriandrum sativum. Linn methanolic extract in Streptozocin induced diabetic wistar Albino rats

Ahmed S. K., Chakrapani Cheekavolu, Sampath D., Sunil M.

Abstract


Background: Diabetes prevalence is estimated to increase annually. Numerous people use traditional medicine, such as India also considered as the diabetic capital in the world. Diabetes is a metabolic disorder characterized by disturbances in lipid, carbohydrate and protein metabolism. The present study to evaluate the antidiabetic potential of coriandrum sativum. linn fruits methanolic extract in streptozocin induced diabetic wistar albino rats model.

Methods: Diabetes induction in wistar albino rats by administration of streptozocin (50mg/kg, i.p.) in citrate buffer. 30 wistar albino rats were divided into 5 groups (A, B, C, D, E). Group A: served as normal control, whereas Group B: diabetic control, Group C, D methanolic coriandrum sativum Linn. fruits extract (CSFME) at a dose of 100, 200mg/kg orally, Group E was given standard drug Glibenclamide (0.5mg/kg) orally. All groups are administered for the period of 14 consecutive days and blood sugar levels was measured at regular intervals up to end of the study.

Results: This present research study confirms that the test drug compound CSFME has sustained oral hypoglycaemic activity and statistically significant (p ≤0.05) and which is comparable with standard drug Glibenclamide.

Conclusions: This research study confirms that the CSFME has antidiabetic activity against streptozocin induced wistar diabetic albino rats. It could be a novel antidiabetic agent and also a dietary adjunct in the type 2 diabetes management and its complication. Further studies are necessary required to confirm the antidiabetic activity of individual phytochemical compounds of Coriandrum sativum.


Keywords


Antidiabetic, Blood glucose, Coriandrum sativum, Diabetic wistar albino rats, Glibenclamide, Methanolic extract

Full Text:

PDF

References


Raheja BS, Kapor A, Bhaskar A, Sathe SR, Jorgensen LN, Moorthi SR. Diabetes care in India-current studies. JAPI. 2001;49(7):712-22.

Menaka CT, Ravirajsinh NJ, Ansarullah T, Ranjitsinh VD, Ramachnadran AV. Prevention of high fat diet induced insulin resistance in mice by Sida rhomboidea ROXB. Extract. J Health Sci. 2010;56:92-8.

Amos AF, McCarty, DJ, Zimmet P. The rising global burden of diabetes and its complications: estimates and projections by 2010. Diabet. Med. 1997;14(5):5-85.

Sunil C, Latha PG, Suja SR, Shine VJ, Shyamal S, Anuja GI. Effect of ethanolic extract of Pisonia alba Span. leaves on blood glucose levels and histological changes in tissues of alloxan induced diabetic rats. Int J Appl Res Nat Prod. 2009;2:4-11.

Kyriacou A, Ahmed AB. Exenatide use in the management of type 2 diabetes mellitus. Pharmaceuticals. 2010;3:2554-67.

Pandita R, Phadke A, Jagtap A. Antidiabetic effect of Ficus religiosa extract in streptozotocin induced diabetic rats. J Ethnopharmacol. 2010;128(2):462-6.

Vishwakarma SL, Rakesh S, Rajani M, Goyal RK. Evaluation of effect of aqueous extract of Enicostemma littorale Blume in streptozotocin induced type 1 diabetic rats, Indian J. Exp. Biol. 2010;48:26-30.

The Wealth of India, First supplement Series-Raw Material] 2:Cl-Cy, National Institute of Science and Communication, Council of Scientific and Industrial Research, New Delhi, India; 2001:205.

Pullaih T. Encyclopedia of World Medicinal Plants, Vol 2, Regency Publication, New Delhi, India. 2006:1641.

Bently R, Trimen H. Medicinal Plants, Omsons Publications, New Delhi, India, 2002;2:729.

Khare PC. Indian Medicinal Plants, Springer Science Publishers, NY, USA; 2007:174.

Paarakh MP. Coriandrum sativum Linn: A review, Pharmacologyonline News Letters. 2009;3:561-73.

Paarakh MP, Rekha P, Dileep CS, Vedamurthy AB. HPTLC finger profile of Coriandrum sativum Linn. Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2015;6(1):1407-15.

Sangeeta PB, Waseem R, Anil K. Dose dependent effect of Coriandrum sativum seeds on thermal pain stimuli. J Phyto. 2014;3(4):254-8.

Kamempor SF, Langenbez SV, Shajei MN, Ghorbani A, Pourganji M. The analgesic effect of different extracts of aerial parts of Coriandrum sativum in mice. Int J Biomed Sci. 2015;11(1):23-8.

Padmaa MP. Comparison of in vitro antioxidant activity of Coriandrum sativum fruit by soxhlation and maceration extraction technique, Eur J Biomed Pharm Sci. 2014;1:230-40.

Padmaa MP, Jai KS, Rupesh M. Analgesic activity of methanol extract of Coriandrum sativum Linn fruit. World Journal of Pharmacy and Pharm Sci. 2016;5(10):1456-64.

Padmaa MP. Green synthesis of silver nanoparticles using fruits of Coriandrum sativum Linn and its antioxidant activity. Journal of Natural Products and Resources. 2015;1(1):19-22.

Yadav JP, Saini S, Kalia AN, Dangi AS. Hypoglycemic and hypolipidemic activity of ethanolic extract of Salvodora oleoides in normal and alloxan-induced diabetic rats. Indian Journal of Pharmacology. 2008;40(1):23-7.

Papaccio G, Pisanthi FA, Latronico MY, Ammendola E, Galdieri M. Multiple low dose and single high dose treatments with streptozotocin do not generate nitric oxide. J of Cellular Biochemistry. 2000;77:82-91.

Anderson T, Schein PS, McMenamin MG, Cooney DA. Streptozotocin diabetes correlation with extent of depression of pancreatic islet nicotinamide adenine dinucleotide. Journal of Clinical Investigation. 1974;54:672-7.