TY - JOUR AU - Murthy, Aravind Baskar AU - K., Amuthavalli AU - P., Nirmaladevi AU - B., Meenakshi PY - 2022/02/23 Y2 - 2024/03/29 TI - Analysis of cutaneous adverse drug reactions in a tertiary care hospital in South Tamil Nadu JF - International Journal of Basic & Clinical Pharmacology JA - Int J Basic Clin Pharmacol VL - 11 IS - 2 SE - Original Research Articles DO - 10.18203/2319-2003.ijbcp20220406 UR - https://www.ijbcp.com/index.php/ijbcp/article/view/4914 SP - 97-107 AB - <p><strong>Background: </strong>Cutaneous adverse drug reactions (CADRs) are among the most frequently reported adverse drug reactions (10 to 30%) with overall incidence of 6.2/1000 cases in India and 8% of hospitalisation among Dermatology inpatients. The aim was to analyse the CADRs with reference to its prevalence, causative drugs, morphological patterns, polypharmacy and drug reaction severity by Hartwig’s severity assessment scale.</p><p><strong>Methods:</strong> This study was a retrospective study done in the Department of Dermatology, Venereology and Leprosy (DVL) over a period of 5 years (2015 to 2019) from CADR registers. Mean, standard deviation and chi square test were used for statistical analysis. P≤0.05 was considered as statistically significant.</p><p><strong>Results: </strong>A total of 134 cases of CADRs were encountered which comprised 0.2% (2/1000) of total OP census with equal gender ratio and involved most commonly the younger adults. The drug groups mainly responsible were anticonvulsants (24.7%) followed by non-steroidal anti-inflammatory drugs (NSAIDS) (22.5%), antibiotics (20.9%) followed by antiretrovirals (ART) and antituberculous drugs (ATT). The common morphological patterns were acute exanthem (32.2%), exfoliative dermatitis (14.9%) and toxic epidermal necrolysis (14.2%). Over the counter drugs accounted for 25.6% of cases. Around 38.1% were on polypharmacy. In this study, 15.7% had mild CADR, 53.7% had moderate and 30.6% had severe drug reactions with 2.2% mortality based on the Hartwig’s severity assessment scale. Commonest cause of severe CADRs was anticonvulsants and benign CADRs was NSAIDS.</p><p><strong>Conclusions:</strong> Proper history taking and documentation of data, recollection of sequence of events by the patient and drug re-challenge will help us in deciding the causative drug preventing further occurrence.</p> ER -