TY - JOUR AU - R., Velvizhy AU - Pandian J., Johan PY - 2020/07/21 Y2 - 2024/03/29 TI - A prospective comparative efficacy of azilsartan and telmisartan in hypertensive patients JF - International Journal of Basic & Clinical Pharmacology JA - Int J Basic Clin Pharmacol VL - 9 IS - 8 SE - Original Research Articles DO - 10.18203/2319-2003.ijbcp20203140 UR - https://www.ijbcp.com/index.php/ijbcp/article/view/4175 SP - 1232-1235 AB - <p><strong>Background: </strong>Hypertension (HT) is defined as either a sustained systolic blood pressure of greater than 140 mmHg or a sustained diastolic blood pressure of greater than 90 mmHg, according to joint national committee (JNC VIII) on hypertension.</p><p><strong>Methods:</strong> A prospective, open, randomized parallel group comparative study of AZL versus telmisartan was done in patients of stage-I HT. The study included 80 patients, 40 in each group (group I and group II) coming to the Department of Pharmacology, Mahatma Gandhi Medical College and Research Institute, Pillayarkuppam, Pondicherry from January 2016 to December 2017. The study was conducted over 8 weeks. Group-I, patients received azilsartan 40-80 mg per day in divided doses and group-II, patients received telmisartan 40-80 mg per day in divided doses according to severity of hypertension.</p><p><strong>Results:</strong> Patients receiving AZL 40 mg and telmisartan 40 mg showed a significant fall (p&lt;0.05) in systolic blood pressure (SBP) and diastolic blood pressure (DBP) at 4 weeks and 8 weeks, when compared to baseline. The difference in SBP and DBP between group I (AZL) and II (telmisartan) was statistically significant at 4 weeks (p&lt;0.05) and was highly significant at 8 weeks (p&lt;0.001). Adverse effects such as nasopharyngitis, upper respiratory tract infection, gastroenteritis, headache, dizziness, and fatigue were reported with both drugs.</p><p><strong>Conclusions:</strong> Reduction of BP with AZL was more as compared to telmisartan at 4 weeks and 8 weeks. Safety and tolerability were similar in both groups.</p> ER -