TY - JOUR AU - Jaybhaye, Deepali J. AU - Chaudhary, Prashant S. AU - Chandra, Shruti AU - Johar, Sukhmeen PY - 2020/03/24 Y2 - 2024/03/28 TI - Evaluation of anti-asthmatic and anti-cholinergic activity of ethanolic extract of Tectina grandis Linn. bark JF - International Journal of Basic & Clinical Pharmacology JA - Int J Basic Clin Pharmacol VL - 9 IS - 4 SE - Original Research Articles DO - 10.18203/2319-2003.ijbcp20201179 UR - https://www.ijbcp.com/index.php/ijbcp/article/view/3937 SP - 572-576 AB - <p><strong>Background: </strong>Asthma is a chronic disease that affects approximately 300 million people worldwide. <em>Tectona grandis</em> <em>Linn.</em> bark, also known as Teak (English), is traditionally used to treat asthma. However, the scientific data on anti-asthmatic and anti-cholinergic of this plant has got little attention. An attempt has been based on ethanolic extract of bark of <em>Tectona grandis Linn.</em> shown a tremendous effect on asthma when comparative study was done with normal and treated group.</p><p><strong>Methods:</strong> The anti-asthmatic activity of a 95% ethanol and 5% distilled water extract of dried and fresh <em>Tectona grandis Linn.</em> bark, was evaluated against histamine and acetylcholine-induced preconvulsive dyspnea (PCD) in guinea pigs fasted for 24 h were exposed to an atomized fine mist of 2% histamine dihydrochloride and acetylcholine aerosol (dissolved in normal saline) using nebulizer at a pressure of 300 mmHg in the histamine chamber (24×14×24 cm, made of perplex glass. They were divided in groups Mepyramin (8 mg/kg) intraperitonially, atropine aerosol and <em>Tectona grandis</em> bark formulation (2.5, 5, 10 gm/kg) were administered orally 30 min prior to exposure. Animals, which did not develop typical asthma within 6 minutes, were taken as protected.</p><p><strong>Results:</strong> Ethanolic extract of <em>Tectona grandis Linn.</em> bark at 5 and 10 gm/kg significantly reduce bronchoconstriction as compared to control group along with significant mast cell stabilization activity.</p><p><strong>Conclusions:</strong> In conclusion, the present study shows that the ethanolic bark extract of <em>Tectona grandis Linn.</em> has potential antiasthamatic and antichlolinergic action in histamine and acetylcholine broncocontraction in guinea pigs.</p> ER -