TY - JOUR AU - V., Venkatadri T. AU - A.K., Afzal Khan PY - 2016/12/30 Y2 - 2024/03/28 TI - Wound healing suppressant effect of vincristine reversed by vitamin A: an experimental study JF - International Journal of Basic & Clinical Pharmacology JA - Int J Basic Clin Pharmacol VL - 5 IS - 3 SE - Original Research Articles DO - 10.18203/2319-2003.ijbcp20161552 UR - https://www.ijbcp.com/index.php/ijbcp/article/view/379 SP - 962-964 AB - <p><strong>Background: </strong>Use of antineoplastic drugs pre and postoperatively have shown to adversely affect the healing of surgical wounds. Vincristine is an antineoplastic drug with a wide range of antitumor activity. Prior studies have demonstrated that vincristine impairs skin wound healing.</p><p><strong>Methods:</strong> In this study we investigated the effect of vitamin A on vincristine induced suppression of healing in two wound models, viz: incision and dead space in rats. Hydroxyproline (measure of collagen) was estimated colorimetrically and breaking strength of the wound and granulation tissue was measured.</p><p><strong>Results:</strong> Vincristine (60 mcg/Kg intraperitoneally, on the 3<sup>rd</sup> wounding day) significantly reduced breaking strength in both incision and dead space wound models. Vitamin A (5000 I.U, Subcutaneously on alternate days) by itself did not alter any of the parameters studied but reversed the suppressant effects of vincristine on wound healing.</p><p><strong>Conclusions:</strong> Vitamin A by itself produced little effect on healing except a modest increase in granulation mass. But it significantly reversed the healing suppressant effects of vincristine.</p> ER -