TY - JOUR AU - Pokala, Naveen AU - Sayeli, Vijaykumar AU - T., Jayasree PY - 2019/06/24 Y2 - 2024/03/29 TI - Evaluation of antipyretic activity of alcoholic extract of Murraya koenigii leaves in rabbits JF - International Journal of Basic & Clinical Pharmacology JA - Int J Basic Clin Pharmacol VL - 8 IS - 7 SE - Original Research Articles DO - 10.18203/2319-2003.ijbcp20192653 UR - https://www.ijbcp.com/index.php/ijbcp/article/view/3383 SP - 1577-1581 AB - <p><strong>Background: </strong>The present study was carried out to evaluate the antipyretic activity of alcoholic extract of <em>Murraya koenigii</em> leaves in rabbits by using PGE1 induced hyperpyrexia method. We found that not much work has been done on the antipyretic effect of this plant.</p><p><strong>Methods:</strong> Laboratory breed New Zealand strains of rabbits of either sex weighing 1000-1500 gm were used in the study. The animals were divided into five groups (n=6). The rabbits of all the groups were made febrile by injecting misoprostol (PGE1) subcutaneously in the dose of 100 mcg/kg.  For group 1 and 2, normal saline 2ml/kg as control and aspirin 28mg/kg as standard were given respectively. Alcoholic extract of <em>Murraya koenigii</em> leaves in the doses of 200, 400 and 800mg/kg were administered in remaining three groups respectively. Rectal temperatures were recorded with help of digital thermometer for every 30 min after drug treatment.</p><p><strong>Results:</strong> Alcoholic extract of <em>Murraya koenigii</em> produced highly significant (p&lt;0.001) antipyretic effect in 400 and 800 mg/kg doses. But onset of action was fast with 800mg/kg dose.</p><p><strong>Conclusions:</strong> This study concludes that Alcoholic extract of <em>Murraya koenigii</em> has fast onset of action and also exhibited sustained anti pyretic action in New Zealand rabbits.</p> ER -