TY - JOUR AU - Datchanamurthy, Barathane AU - D., Mythireyi AU - M., Dhivyashanthi C. PY - 2019/03/23 Y2 - 2024/03/29 TI - Evaluation of antiulcer activity of ethanolic leaf extract of Coccinia grandis in indomethacin induced gastric ulcer model JF - International Journal of Basic & Clinical Pharmacology JA - Int J Basic Clin Pharmacol VL - 8 IS - 4 SE - Original Research Articles DO - 10.18203/2319-2003.ijbcp20191094 UR - https://www.ijbcp.com/index.php/ijbcp/article/view/3200 SP - 629-634 AB - <p><strong>Background: </strong>Gastric mucosal ulceration is the most common adverse effect with NSAIDS. Antacids, H2 blockers and PPIs are considered novel in treating ulcers but are not devoid of side effects. Hence, there a need for a drug which is effective against NSAID induced ulcers with no side effects. <em>Coccinia grandis</em> plant is traditionally used for the treatment of gastric/peptic ulcers. Hence, this study has been undertaken to scientifically validate the antiulcer activity of <em>Coccinia grandis</em> leaves against indomethacin induced gastric ulcer model.</p><p><strong>Methods:</strong> Following preparation of the extract, 24 Wistar rats were divided into 4 groups with 6 rats in each group (n=6). Group 1 received 1% CMC, group 2 received 1% CMC +indomethacin 40 mg/kg, group 3 received ethanolic leaf extract of <em>Coccinia grandis</em> 200 mg/kg +indomethacin 40 mg/kg and group 4 received omeprazole (2 mg/kg) +indomethzacin 40 mg/kg for 7 days. Calculation of ulcer score was done using ulcer index and percentage protection.</p><p><strong>Results:</strong> The ulcer index score (2.12±0.21) and percentage protection (69.71%) was comparable with the standard drug (1.76±0.11, 74.85%) respectively.</p><p><strong>Conclusions:</strong> The ethanolic leaf extract of <em>Coccinia grandis</em> showed significant antiulcer activity against indomethacin-induced gastric ulcer. Further studies are warranted to elucidate the exact mechanism of antiulcer activity.</p> ER -