TY - JOUR AU - Borde, Manjusha K. AU - Mohanty, Ipseeta Ray AU - Maheshwari, Ujwala AU - Suman, Rajesh Kumar AU - Deshmukh, Y. A. PY - 2019/02/23 Y2 - 2024/03/28 TI - DPP-4 inhibitory activity and myocardial salvaging effects of Commiphora mukul in experimental diabetes JF - International Journal of Basic & Clinical Pharmacology JA - Int J Basic Clin Pharmacol VL - 8 IS - 3 SE - Original Research Articles DO - 10.18203/2319-2003.ijbcp20190668 UR - https://www.ijbcp.com/index.php/ijbcp/article/view/3129 SP - 575-583 AB - <p><strong>Background: </strong><em>Commiphora mukul </em>(Burseraceae) is commonly known as Guggul in Ayurveda. Several studies have reported antidiabetic activity of <em>Commiphora mukul</em> but there are no studies to explore the DPP-4 inhibitory activity and myocardial salvaging effects of <em>Commiphora mukul </em>in setting of diabetes mellitus.<strong> </strong>The present study was designed to evaluate the cardioprotective efficacy as well as safety of the medicinal plant <em>Commiphora mukul </em>(Guggul) in the experimental model of myocardial infarction co-existing with diabetes.</p><p><strong>Methods:</strong> Diabetes was induced with single dose of streptozotocin (STZ): 45mg/kg ip and myocardial infarction was produced by administering isoproterenol (ISP): (85mg/kg, sc) to rats 24 and 48 h prior to scarification (5<sup>th</sup> week). After the confirmation of diabetes on 7<sup>th</sup> day (glucose&gt;200mg/dl), vildagliptin (10 mg/kg) and <em>Commiphora mukul </em>(200 mg/kg) were administered orally from 1<sup>st</sup> to 5<sup>th</sup> week (4 weeks). At the end of experimental period, normal control, diabetic-isoproterenol control, vildagliptin and <em>Commiphora mukul</em> group rats were sacrificed for further biochemical investigations as well as histopathological evaluation.</p><p><strong>Results:</strong> <em>Commiphora mukul</em> treatment demonstrated significant antidiabetic as well as myocardial salvaging effects as indicated by restoration of blood glucose, HbA1c and CPK-MB serum DPP-4, hs-CRP levels as compared to diabetic ISP control<strong> </strong>group. In addition, <em>Commiphora mukul</em> showed significant cardioprotection as indicated by positive correlation between cardiac marker CPK-MB and serum DPP-4. The histopathological assessment of heart, pancreas and biochemical indices of injury confirmed the cardioprotective effects of <em>Commiphora mukul</em>. In addition, <em>Commiphora mukul</em> was found to be safe to the liver and kidney.</p><p><strong>Conclusions:</strong> The natural DPP-4 inhibitor <em>Commiphora mukul</em> demonstrated significant cardioprotective effects in experimental model of myocardial infarction co-existing with diabetes.</p> ER -