TY - JOUR AU - Bandyopadhyay, Chandrakana AU - Manna, Alak AU - De, Soumita AU - Yasmin, Nafisha AU - Bauri, Ajay K. AU - Chattopadhyay, Subrata AU - Chatterjee, Mitali PY - 2019/02/23 Y2 - 2024/03/29 TI - Anti-tumor effect of fruit rind of Myristica malabarica in an Ehrlich ascites carcinoma model JF - International Journal of Basic & Clinical Pharmacology JA - Int J Basic Clin Pharmacol VL - 8 IS - 3 SE - Original Research Articles DO - 10.18203/2319-2003.ijbcp20190648 UR - https://www.ijbcp.com/index.php/ijbcp/article/view/3110 SP - 383-387 AB - <p><strong>Background: </strong>Among the various modalities of anti-cancer treatment, cancer chemotherapy plays a very vital role. The alarming side effects being its main drawback leads to relentless research for newer agents. A new natural agent with promising anti-cancer properties from <em>in-vitro </em>studies leads to this study. Here we have evaluated the anti-tumor activity of a crude extract of fruit rind of <em>Myristica malabarica</em> in an Ehrlich ascites carcinoma model in mice.</p><p><strong>Methods:</strong> A murine model of cancer was established with i.p. inoculation of Ehrlich Ascites carcinoma (EAC) cells; animals were divided into five groups (including normal control) to observe the inhibitory effect of a crude extract of the fruit rind of <em>Myristica malabarica/rampatri </em>(0-100mg/kg b.w. i.p.) as compared with methotrexate (0.4mg/kg bw., i.p.). Blood and ascitic fluid were collected on the 10<sup>th</sup> day for analysis.</p><p><strong>Results:</strong> In the EAC model, there was an increase in tumor volume, tumor weight, and tumor packed cell volume, which was decreased by rampatri (50 and 100mg/kg bw) along with an increase in the mean survival time (MST). Rampatri caused minimal alterations in hematological parameters, renal functions remained unchanged but an increase in hepatic SGOT was demonstrated.</p><p><strong>Conclusions:</strong> The crude extract of rampatri (containing Malabaricones) exhibited significant anti-tumor activity with minimal effect on hematological and renal functions.</p> ER -