TY - JOUR AU - N., Shiva Murthy AU - V., Srinivas AU - M., Shanthi PY - 2018/12/24 Y2 - 2024/03/29 TI - Anti-inflammatory and ulcerogenic activities of thiazolidine-4-ones in rats JF - International Journal of Basic & Clinical Pharmacology JA - Int J Basic Clin Pharmacol VL - 8 IS - 1 SE - Original Research Articles DO - 10.18203/2319-2003.ijbcp20185155 UR - https://www.ijbcp.com/index.php/ijbcp/article/view/2965 SP - 8-15 AB - <p><strong>Background: </strong>NSAIDS are associated with side effects and research should continue for developing safer drugs. This study aims to evaluate newer thiazolidine-4-ones for their anti-inflammatory and ulcerogenic activities in wister rats.</p><p><strong>Methods:</strong> Five groups of wister rats, 6 in each were used.  Anti-inflammatory and ulcerogenic activities of diclofenac (30mg/kg), nimesulide (50mg/kg), thia-1 (50mg/kg) and thia-2 (50mg/kg) are compared with control group (4% Gum Acacia). Carrageenin-induced paw edema, formaline induced acute peritonitis and cotton pellet-induced granulomatous tissue formation models were used for evaluating anti-inflammatory activity. After removing cotton pellets with granuloma on 8<sup>th</sup> day gastric ulcerogenicity was assessed by using macroscopic and microscopic scoring of ulcers.</p><p><strong>Results:</strong> Diclofenac, nimesulide and thia 2 reduced both paw edema and peritoneal exudate volume significantly (p &lt;0.01). Wet weight of cotton pellets reduced significantly (p &lt;0.01) by diclofenac, nimesulide and thia 2. Diclofenac (p &lt;0.01) and thia 2 (p &lt;0.05) reduced dry weight of cotton pellets significantly. nimesulide and thia-1 reduced it by 19.14% and 2.68% respectively and was considered statistically not significant (p&gt;0.05). Nimesulide, thia-1 and thia-2 did not increase gastric ulcer score significantly (p &gt;0.05). Diclofenac increased ulcer score significantly (p &lt;0.01).</p><p><strong>Conclusions:</strong> Thia-2 demonstrated significant anti-inflammatory activity in acute and chronic models. In addition to inhibition of cyclooxygenase pathway, PPAR agonistic activity may be involved in its anti-inflammatory activity.  No significant ulcerogenicity was observed on comparing with nimesulide and control. Further in-vitro and in-vivo studies are recommended to confirm the results of this study.</p> ER -