TY - JOUR AU - Jha, Anuja AU - Agrawal, Manju AU - Neral, Arvind AU - Hishikar, Rajesh AU - Maheshwari, Basant PY - 2018/02/22 Y2 - 2024/03/29 TI - Escherichia coli as uropathogen: antibiotic susceptibility profiling JF - International Journal of Basic & Clinical Pharmacology JA - Int J Basic Clin Pharmacol VL - 7 IS - 3 SE - Original Research Articles DO - 10.18203/2319-2003.ijbcp20180655 UR - https://www.ijbcp.com/index.php/ijbcp/article/view/2242 SP - 433-438 AB - <p><strong>Background: </strong>Empirically chosen antibiotics based on the local resistance pattern of uropathogens remain the principle treatment of urinary tract infections (UTI).</p><p><strong>Methods:</strong> Antibiogram of most frequent uropathogen was determined. Based on the antibiogram result, authors compared effectiveness of drugs recommended for UTI by National centre for disease control (NCDC), India, and assessed age and gender based variability in the effectiveness of these drugs.</p><p><strong>Results:</strong> 1278 urine samples were accounted, of which 405 samples showed significant growth. <em>E. coli</em> was the most common uropathogen (n=146, 36%) followed by enterococcus species (31%) and <em>Klebsiella pneumoniae</em> (10%). Using McNemar’s test authors found that nitrofurantoin (90% sensitivity) was statistically the most effective drug among drugs recommended by NCDC for uncomplicated cystitis. Furthermore, authors used Fisher’s exact test on adults and paediatrics and found that significant difference in effectiveness was observed for nitrofurantoin (p-value &lt;0.001) and cotrimoxazole (p-value 0.034). Using logistic regression, authors found that with age, effectiveness of ciprofloxacin and cotrimoxazole deteriorate significantly (p-value 0.021 and 0.002 respectively). Additionally, authors observed that cotrimoxazole has significantly better efficacy in males compared to females (p-value 0.022).</p><p><strong>Conclusions:</strong> In accordance with present study, nitrofurantoin can be used as first line treatment for uncomplicated cystitis. Age and gender should be considered while prescribing empirical treatment for UTI. Periodic surveillance should be carried out to identify the on-going pattern of antibiogram to update the guideline for empirical therapy.</p> ER -