TY - JOUR AU - ., Nishikant AU - Singh, Janardhan AU - Sood, Sushma AU - ., Vijayshanker PY - 2017/01/30 Y2 - 2024/03/29 TI - Effect of gamma linolenic acid pretreatment on diabetic neuropathy in rats JF - International Journal of Basic & Clinical Pharmacology JA - Int J Basic Clin Pharmacol VL - 2 IS - 3 SE - Original Research Articles DO - UR - https://www.ijbcp.com/index.php/ijbcp/article/view/1263 SP - 320-325 AB - <p><strong>Background:</strong> The present study was planned to evaluate the preventive effects of gamma linolenic acid (GLA) on STZ induced diabetic neuropathy</p><p><strong>Methods:</strong> Streptozotocin (STZ) induced diabetic neuropathy in rats was monitored by measuring blood sugar levels, body weight, motor nerve conduction velocity (MNCV) and nociception. Forty rats were divided into 4 groups of 10 each. Group 1: control (vehicle), Group 2: STZ (50 mg/kg, i.v., single injection), Group 3: Gamma linolenic acid (50 mg/ kg, p.o., daily + STZ), Group 4: STZ + Insulin (4 units/kg, s.c., bid). Similar protocol was used for other parameters also.</p><p><strong>Results:</strong> Gamma linolenic acid pretreatment failed to reduce blood sugar levels in diabetic rats but prevented deterioration of motor nerve conduction velocity as compared to STZ diabetic rats. A significant weight gain was observed in STZ diabetic rats pretreated with GLA as compared to rats received STZ alone. Hyperalgesia induced by STZ was antagonized by GLA</p><p><strong>Conclusions:</strong> Thus gamma linolenic acid prevents the development of neuropathic changes induced by STZ in rats.</p> ER -