TY - JOUR AU - Manjare, Rahul M. AU - Tilak, Abhijit V. AU - Rane, Bhalchandra T. AU - Dabhade, Sanjay A. AU - Bhalsinge, Rahul R. AU - Patil, Harshal P. PY - 2017/01/29 Y2 - 2024/03/29 TI - Study of effects of donepezil and aspirin on working memory in rats using electroconvulsive shock model JF - International Journal of Basic & Clinical Pharmacology JA - Int J Basic Clin Pharmacol VL - 3 IS - 6 SE - Original Research Articles DO - UR - https://www.ijbcp.com/index.php/ijbcp/article/view/1178 SP - 1012-1015 AB - <p class="ABS"><span class="Bold">Background:</span> Memory is the most common cognitive ability lost with dementia commonly seen in Alzheimer’s disease (AD). Donepezil was the first cholinesterase inhibitor to be licensed in UK for AD. There is preliminary evidence that aspirin decreases the risk and delays the onset of AD. Low dose aspirin users had numerically lower prevalence of Alzheimer’s dementia and had better cognitive function than non-users.</p><p class="ABS"><span class="Bold">Methods:</span> Retention of conditioned avoidance response (CAR) was assessed by using repeated electroconvulsive shocks (ECS) in rats. Rats were divided into five groups: control (pretreated with distilled water), ECS (150 V, 50 Hz, with intensity of 210 mA for 0.5 sec) pretreated, combined aspirin (6.75 mg/kg) and pretreated ECS, combined donepezil (0.32 mg/kg) and pretreated ECS, combined aspirin, donepezil and pretreated ECS groups. Data were analyzed using the Chi-square test and ANOVA.</p><p class="ABS"><span class="Bold">Results:</span> Findings show that administration of ECS daily for 8 days results in transient amnesia and disruption of retention of CAR. Aspirin and donepezil administration significantly increased the retention of CAR in comparison to ECS. However, aspirin failed to show an increase in the retention of CAR as compared to donepezil. The combination of the two drugs showed statistically significant increase in the retention of CAR than either of these drugs given alone.</p><p class="ABS"><span class="Bold">Conclusion:</span> Neuroinflammation plays an important role in the pathophysiology of neurodegenerative disorder like AD. Combination of aspirin with donepezil increased the nootropic and neuroprotective effect of aspirin and thus may hold great clinical significance in such disorders.</p> ER -