TY - JOUR AU - Mamatha, M. AU - Manasa, V. AU - Vijusha, M. AU - Suthakaran, R. PY - 2017/01/29 Y2 - 2024/03/29 TI - Hepatoprotective activity of methanolic leaves extract of Rostellularia procumbens by using carbon tetrachloride intoxicated rats JF - International Journal of Basic & Clinical Pharmacology JA - Int J Basic Clin Pharmacol VL - 3 IS - 6 SE - Original Research Articles DO - UR - https://www.ijbcp.com/index.php/ijbcp/article/view/1169 SP - 964-969 AB - <p class="ABS"><span class="Bold">Background: </span><span class="Italic">Rostelluria procumbens</span> is a medicinal plant used traditionally in the treatment of asthma, cough and constipation and as an antioxidant etc. it is rich in phytochemical compounds, which are responsible for its biological properties. The present study focused on evaluation of hepatoprotective activity of methanolic extract of <span class="Italic">R. procumbens</span> leaf in carbon tetrachloride (CCl<span class="Subscript">4</span>) induced hepatotoxocity in rats.</p><p class="ABS"><span class="Bold">Methods: </span>In this study, 30 wistar rats were used and grouped into 6 each group contain 6 rats. In this study, CCl<span class="Subscript">4</span> is used as hepatotoxin. Four groups were treated with CCl<span class="Subscript">4</span> and taken as disease control, standard, and two test groups. One group was taken as control treated with saline. Blood samples were collected and estimated serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, alkaline phosphatase and total bilirubin, which are key markers of liver function. The rats were sacrificed and livers were isolated and histopatological studies carried out.</p><p class="ABS"><span class="Bold">Results: </span>On oral administration of methanolic leaves extract of <span class="Italic">R. procumbens </span>to ethanol intoxicated, rats resulted in significant restoration of enzyme levels and also silymarin at a dose of 25 mg/kg. The reversal of increased serum enzymes in ethanol-induced liver damage by the extract may be due to the prevention of leakage of intracellular enzymes by its membrane stabilizing activity.</p><p class="ABS"><span class="Bold">Conclusion: </span>The results confirm that <span class="Italic">R. procumbens </span>have hepatoprotective activity againstCCl<span class="Subscript">4</span> induced hepatotoxicity and significant hepatoprotection seen at 500 mg/kg dose.</p> ER -