TY - JOUR AU - Bai, C. Kumari AU - Padma, L. AU - Mohan, N. T. Madan AU - Veena, D. R. PY - 2017/01/25 Y2 - 2024/03/28 TI - Drug-induced cutaneous adverse drug reactions in dermatology in Dr. B.R. Ambedkar Medical College JF - International Journal of Basic & Clinical Pharmacology JA - Int J Basic Clin Pharmacol VL - 3 IS - 4 SE - Original Research Articles DO - UR - https://www.ijbcp.com/index.php/ijbcp/article/view/1058 SP - 706-710 AB - <p class="ABS" align="left"><span class="Bold">Background:</span> Cutaneous adverse drug reactions (ADRs) affect 2-3% of hospitalized patients. The severity varies from mild itching to life-threatening Stevens-Johnson syndrome (SJS). Hence, this study was undertaken to emphasize the need to report ADRs.</p><p class="ABS" align="left"><span class="Bold">Methods:</span> The study was carried out in the Department of Dermatology in Dr. B.R Ambedkar Medical College Hospital from June to December 2012. Naranjo’s algorithm was used to determine the causality of an ADR. Informed consent was obtained from each patient, and thorough clinical examination was conducted. All the information was carefully recorded in a pre-designed proforma. To establish the etiologic agent for a particular type of reaction, attention was paid to the drug history, temporal correlation with the drug, duration of the reaction, morphology of the reaction, associated mucosal or systemic involvement, improvement of lesions on withdrawal of the drug.</p><p class="ABS" align="left"><span class="Bold">Results: </span>In the present study, all the age groups were affected with cutaneous ADRs, with a higher incidence in age group between 31 and 40 years, non-steroidal anti-inflammatory drugs (NSAIDs) (41.66%) were most commonly observed drug, followed by anti-microbials (25%) and anti-convulsants (21.66%). Fixed drug eruptions (FDE) (46.66%) most commonly observed cutaneous reaction, followed by SJS (16.66%), erythema multiformae (16.66%) most commonly observed ADRs.</p><p class="ABS" align="left"><span class="Bold">Conclusions:</span> ADRs are potentially avoidable causes for seeking medical care. FDE was most common ADR and NSAIDs were most common causative agents in our study. ADRs can be prevented by avoiding polypharmacy, obtaining history of any previous skin reaction and the causative agent.</p> ER -