@article{Mathai_Nayak_Rao_Bhat_Vinodraj_Chandralekha_Rajesh_Chethan_2017, title={Comparison of the efficacy of sitagliptin with pioglitazone on dexamethasone-induced hepatic steatosis, dyslipidemia, and hyperglycemia in albino rats}, volume={4}, url={https://www.ijbcp.com/index.php/ijbcp/article/view/865}, abstractNote={<p class="ABS" align="left"><span class="Bold">Background: </span>Sitagliptin is a dipeptidyl peptidase type 4 inhibitor. This study was done to assess the insulin-sensitizing effect of sitagliptin on Wistar albino rats by means of surrogate measures.</p><p class="ABS" align="left"><span class="Bold">Methods: </span>There were four groups of six rats each. First group received dexamethasone alone in a dose of 8 mg/kg intraperitoneally for 6 days to induce metabolic changes and considered as dexamethasone control. Second group received sitagliptin 100 mg/kg orally 6 days before dexamethasone and 6 days during dexamethasone administration. Third group received pioglitazone 45 mg/kg orally 6 days before dexamethasone and 6 days during dexamethasone administration. Fourth group did not receive any medication and was considered as normal control. Fasting blood sugar, lipid profile, blood sugar 2 hrs after glucose load (postprandial blood sugar), liver weight, liver volume, and histopathological analysis were done.</p><p class="ABS" align="left"><span class="Bold">Results: </span>The effects of sitagliptin were compared with that of pioglitazone. Dexamethasone caused hepatomegaly, dyslipidemia, and hyperglycemia. Both pioglitazone and sitagliptin significantly reduced hepatomegaly, dyslipidemia, and hyperglycemia (p<0.01). Reduction of blood sugar levels after glucose load was significant with pioglitazone in comparison to sitagliptin (p<0.01).</p><p class="ABS" align="left"><span class="Bold">Conclusions: </span>Sitagliptin has comparable efficacy to pioglitazone in dexamethasone-induced hepatomegaly, dyslipidemia, and fasting hyperglycemia.</p>}, number={1}, journal={International Journal of Basic & Clinical Pharmacology}, author={Mathai, Paul and Nayak, Nagendra and Rao, Mamtha and Bhat, G. M. Nitasha and Vinodraj, K. and Chandralekha, N. and Rajesh, D. and Chethan, T. K.}, year={2017}, month={Jan.}, pages={60–64} }