@article{M._G._2020, title={Anti-fungal activity of Carica papaya leaf extract against candida albicans and its synergy with fluconazole: an in-vitro study}, volume={10}, url={https://www.ijbcp.com/index.php/ijbcp/article/view/4495}, DOI={10.18203/2319-2003.ijbcp20205547}, abstractNote={<p><strong>Background: </strong>In this study objectives were to evaluate the antifungal activity in increasing concentrations of ethanolic extract and aqueous extract of <em>Carica papaya</em> against <em>Candida albicans</em> and to assess the synergistic activity of ethanolic extract of <em>Caricia papaya</em> with flucanazole as a potential antifungal.</p><p><strong>Methods:</strong> The aim of the study was to evaluate the antifungal activity in increasing concentrations, 500 µl/ml, 750 µl/ml and 1000 µl/ml of ethanolic extract and aqueous extract of caricia papaya against <em>Candida albicans</em> and the synergistic activity with Fluconazole was assessed by observing the zone of inhibition in agar disc diffusion assay and by observing the turbidity in minimum inhibitory concentration (MIC) assay.</p><p><strong>Results:</strong> It was observed that ethanolic extract of <em>Carica papaya</em> leaf showed significant antifungal activity in higher concentration of 1000µg/ml with zone diameter of 11.97±0.15 mm in disc diffusion assay and MIC of 350 µg/ml. The ethanolic extract of <em>Carica papaya</em> leaf with fluconazole showed synergistic activity with zone diameter of 13.6±0.45 mm in disc diffusion assay and MIC was 125µg/ml, whereas the standard drug Fluconazole’s zone of inhibiton was 12.83±0.9 in disc diffusion and MIC was 500 µg/ml.</p><p><strong>Conclusions:</strong> From this study, we can safely conclude that the <em>Carica papaya</em> leaf extract has a significant antifungal property and exhibit synergistic effect when used with fluconazole.</p>}, number={1}, journal={International Journal of Basic & Clinical Pharmacology}, author={M., Nilofer Noorie and G., Chenthamarai}, year={2020}, month={Dec.}, pages={101–105} }