@article{Choudhury_Devi_Borah_2019, title={Evaluation of antiatherogenic effect of Alternanthera brasiliana Linn kuntz in rats on atherogenic diet}, volume={8}, url={https://www.ijbcp.com/index.php/ijbcp/article/view/3309}, DOI={10.18203/2319-2003.ijbcp20192180}, abstractNote={<p><strong>Background: </strong>Hypercholesterolaemia is a major risk factor for systemic atherosclerosis and a well-known etiological factor for cardiovascular diseases and its complications which is a leading cause of mortality worldwide. In a recent study, the antihyperlipidemic activity of dried leaves extract of <em>Alternanthera brasiliana</em> has been evaluated. Hence, the present study was undertaken to investigate the anti-atherosclerotic potential of the methanolic extract of the leaves of <em>Alternanthera brasiliana </em>L. Kuntz (MEAB) in high fat diet induced hypercholesterolemic rat model.</p><p><strong>Methods:</strong> Thirty (30) wistar albino rats of either sex were randomly divided into five groups: first two groups received normal diet and high fat diet respectively and the remaining three groups received high fat diet supplemented with methanolic extract of <em>Alternanthera brasiliana</em> (MEAB) administered orally daily at two different doses: 200 mg/kg and 400 mg/kg and Atorvastatin 10 mg/kg/day orally as standard respectively. Serum total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL-C) and high density lipoprotein (HDL-C) was estimated after 12 weeks. Atherogenic index was calculated from the results of lipid profile. At the end, the aorta was removed for assessment of atherosclerotic plagues.</p><p><strong>Results:</strong> Our results showed that MEAB possessed significant cholesterol lowering potency as indicated by decrease in serum total cholesterol (TC), triglyceride (TG) and low density lipoprotein (LDL-C) accompanied by an increase in serum high density lipoprotein (HDL-C) and reduces the atherosclerotic lesion of aorta (p <0.05).</p><strong>Conclusions:</strong> These results strongly suggests that MEAB can prevent the progress of atherosclerosis likely due to the effect of <em>A. brasiliana</em> on serum lipoproteins and its antioxidant and anti-inflammatory properties. It could be a potential therapy for the prevention and treatment of atherosclerosis.}, number={6}, journal={International Journal of Basic & Clinical Pharmacology}, author={Choudhury, Urmi and Devi, Tarali and Borah, Asha}, year={2019}, month={May}, pages={1172–1178} }