@article{R._R._J._M._2019, title={Prescribing pattern and adverse drug reactions of cardiovascular drugs in out-patient department of a tertiary care hospital}, volume={8}, url={https://www.ijbcp.com/index.php/ijbcp/article/view/3221}, DOI={10.18203/2319-2003.ijbcp20191114}, abstractNote={<p><strong>Background: </strong>The main objective of prescription pattern analysis is to assess the rationality of drug use. It has been found that cardiovascular disease is the most frequent cause of morbidity and mortality throughout the world. This study is to estimate the prescribing pattern and adverse drug reactions in patients with cardiovascular diseases.</p><p><strong>Methods:</strong> This prospective observational study was conducted for a period of 2 months in cardiology outpatient department.100 patients who fulfilled the study criteria were observed. The central drug standard control organisation (CDSCO) reporting forms were used for the collection of adverse drug reactions. Causality assessment was done by using the World Health Organization Collaborating Centre for International Drug Monitoring, the Uppsala Monitoring Centre (WHO-UMC) scoring system and severity assessment by modified Hartwig and Siegel scale.</p><p><strong>Results:</strong> The study group consists of 79% male and 21% females. Average number of drugs per prescription was 4.65. Most commonly prescribed drugs were antiplatelets (32%) followed by statins (18.27%) and the least common were calcium channel blockers (1.72%) and cardiac glycosides (0.86%). A total of 174 adverse drug reactions were reported out of which 24.7% were myalgia due to statins, 15.5% were cough due to angiotensin converting enzyme inhibitors and 14.3% were gastritis due to antiplatelets.</p><p><strong>Conclusions:</strong> Antiplatelets, statins and angiotensin converting enzyme inhibitors dominated the prescribing pattern. Myalgia, cough, gastritis, insomnia by atorvastatin, enalapril, aspirin, beta blockers respectively were found to be the most commonly reported ADRs among the cardiovascular drugs.</p>}, number={4}, journal={International Journal of Basic & Clinical Pharmacology}, author={R., Nalini and R., Mansoora Shahiba and J., Ezhil Ramya and M., Kannan S.}, year={2019}, month={Mar.}, pages={767–771} }