@article{G._Sivaraman_Dutta_K. R._2018, title={Comparative prospective randomized open label trial of synbiotic (bifilac) as an add on therapy with standard treatment in patients with aphthous ulcer}, volume={7}, url={https://www.ijbcp.com/index.php/ijbcp/article/view/2388}, DOI={10.18203/2319-2003.ijbcp20181628}, abstractNote={<p><strong>Background: </strong>To trial the safety, efficacy and rapidity of response to a lozenges containing synbiotic in patients with minor aphthous ulcer.</p><p><strong>Methods:</strong> A total of 60 patients were enrolled for the trial after obtaining IEC approval and randomly allocated into two groups. Control “Group A” was administered with conventional treatment i.e., zytee and B complex for 2 weeks and trial “Group B” was administered with Bifilac along with conventional treatment for 2 weeks. The results of this trial were analyzed both subjectively and objectively.</p><p><strong>Results:</strong> Comparing with control group, where standard treatment was used with analgesics and B-complex, the trial group showed a quick relief of pain and helped in reducing mean size of ulcer.</p><p><strong>Conclusions:</strong> This trial was done with synbiotic lozenges in minor aphthous ulcers and it proved to be better alternative for them. Moreover, synbiotics have no adverse effects.</p>}, number={5}, journal={International Journal of Basic & Clinical Pharmacology}, author={G., Sasikala and Sivaraman, Malar and Dutta, Trayambak and K. R., Dhanasekar}, year={2018}, month={Apr.}, pages={878–881} }