@article{Tiwari_Gudsurkar_2017, title={Assessment of oral hypoglycaemic activity of water soluble extract of aloe vera and its interaction with glipizide in alloxan induced diabetic Wistar Rats}, volume={6}, url={https://www.ijbcp.com/index.php/ijbcp/article/view/1886}, DOI={10.18203/2319-2003.ijbcp20173149}, abstractNote={<p><strong>Background: </strong>Assessment of oral hypoglycaemic activity of water soluble extract of Aloe vera and its interaction with Glipizide in Alloxan induced diabetic Wistar rats.</p><p><strong>Methods:</strong> Under standard condition of testing, alloxan induced diabetic rats were kept in fasting state of 8 hours and then glucose in dose of 1gm/kg was given PO by feeding tube. There after water soluble extract of aloe vera in dose of 200mg/kg BW dissolves in 1ml of Distilled water (DW) to test group 1, Glipizide in dose of 2.5mg/kg BW dissolved in 1ml DW was given to standard group. Test group 2 received combination of Aloe vera 200mg/kg BW and Glipizide in dose of 2.5mg/kg BW dissolved in 1ml Dw. Control group received 1ml of Distilled water. Blood sugars levels of all Rats in each group were checked with Glucometer.</p><p><strong>Results:</strong> Clinically and statistically significant glucose lowering effect was observed in groups administered with Aloe vera and better results were observed in group receiving Aloe vera and Glipizide combination.</p><p><strong>Conclusions:</strong> Water soluble extract of aloe vera has significant hypoglycaemic activity and the results showed that co-administration of Aloe vera and Glipizide has superior hypoglycaemic activity compared to Aloe vera and Glipizide given Individually.</p>}, number={8}, journal={International Journal of Basic & Clinical Pharmacology}, author={Tiwari, Vikalp and Gudsurkar, Gopal}, year={2017}, month={Jul.}, pages={1917–1920} }