@article{Dudhgaonkar_Mahajan_Deshmukh_Admane_Khan_2017, title={Evaluation of anti-depressant effect of lemon grass (Cymbopogon citratus) in albino mice}, volume={3}, url={https://www.ijbcp.com/index.php/ijbcp/article/view/1048}, abstractNote={<p class="ABS" align="left"><span class="Bold">Background: </span>Depression is a common serious psychiatric disorder and the available anti-depressant treatments are associated with many unwanted side-effects. Thus, various herbal products have been tried. The advantages of herbal treatments would include its complementary nature to the conventional treatment, thus making the latter a safer and cheaper option for depressive disorders. The objective of the present study was to evaluate the anti-depressant activity of lemon grass (<span class="Italic">Cymbopogon citratus</span>) in albino mice and compare it with Imipramine.</p><p class="ABS" align="left"><span class="Bold">Methods: </span>A total of 60 Swiss albino mice weighing around 20-40 g of either sex were divided into 10 groups (n=6). They were orally administered with tween 80, as a control, 20 mg/kg imipramine (standard), 5 mg/kg and 10 mg/kg <span class="Italic">C. citratus</span> (test drugs), and combination of imipramine (10 mg/kg) and <span class="Italic">C. citratus</span> (10 mg/kg).  Duration of immobility was observed for last 4 mins of total 6 mins period in groups 1-5 for forced swimming test (porsolt test) and groups 6-10 for tail suspension test each on 1st, 8th and 15th day and recorded as mean±standard error of the mean. Results were analyzed by one-way analysis of variance, followed by Tukey’s post-hoc test.</p><p class="ABS" align="left"><span class="Bold">Results: </span>Lemon grass at the above doses significantly reduced the immobility time in both the tests compared with the control (<0.05). The reduction in the duration of immobility at the dose of 10 mg/kg was comparable to imipramine.</p><p class="ABS" align="left"><span class="Bold">Conclusions:</span> The essential oil of lemon grass (<span class="Italic">C. citratus</span>) has significant anti-depressant activity comparable to imipramine.</p>}, number={4}, journal={International Journal of Basic & Clinical Pharmacology}, author={Dudhgaonkar, Sujata and Mahajan, Manali and Deshmukh, Swapnil and Admane, Pallavi and Khan, Huma}, year={2017}, month={Jan.}, pages={656–660} }