Evaluation of anti-inflammatory activity of ethanolic extract of Cananga odorata Lam in experimental animals

Authors

  • Yasmeen A. Maniyar Department of Pharmacology, S. N. Medical College, Bangalkote, Karnataka, India
  • C. H. Janaki Devi Department of Pharmacology, S. N. Medical College, Bangalkote, Karnataka, India

Keywords:

Ethanolic extract, Cananga odorata Lam, Anti-inflammatory activity

Abstract

Background: The current study evaluates the anti-inflammatory activity of ethanolic extract of Cananga odorata Lam (EECO) in experimental animals.

Methods: Acute toxicity test was done following OECD guidelines. Carrageenan induced paw edema method in Wistar Albino rats were used in this study. Aspirin in the dose of 300 mg/kg was used as the standard drug and three doses of EECO (100 mg/kg, 200 mg/kg and 400 mg/kg b.w. p.o) were used as the test drug. The results were measured at 1st hr, 3rd hr and 5th hr after carrageenan injection.

Results: EECO in the doses of 100 mg/kg, 200 mg/kg and 400 mg/kg showed highly significant anti-inflammatory activity (p<0.001) (p<0.001) (p<0.001) at 3rd hr and (p<0.001) (p<0.001) (p<0.001) 5th hr, respectively. In doses of 100 mg/kg, 200 mg/kg, and 400 mg/kg of EECO showed the percentage of inhibition of 62.9% which is more than the standard drug aspirin, which showed 60.14% inhibition.

Conclusion: EECO has significant anti-inflammatory activity.

References

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Published

2017-01-21

How to Cite

Maniyar, Y. A., & Devi, C. H. J. (2017). Evaluation of anti-inflammatory activity of ethanolic extract of Cananga odorata Lam in experimental animals. International Journal of Basic & Clinical Pharmacology, 4(2), 354–357. Retrieved from https://www.ijbcp.com/index.php/ijbcp/article/view/926

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Original Research Articles