Estimation of thyroid profile in patients with diabetes mellitus in New Civil Hospital, Surat

Khushbu Vaghasiya, Chetna Patel, Kapil Shahane, Nitesh Gamit, Ashish Zala, Aashal Shah


Background: Diabetes mellitus (DM) and thyroid diseases are the two common endocrinopathies seen commonly in the population. There is inter-dependence between insulin and thyroid hormones for normal cellular metabolism so that DM and thyroid diseases can mutually influence the other disease process. The excess or deficit of one hormone may result in functional derangement of other. Diabetes being a most common endocrine metabolic disorder, the variety of thyroid abnormalities may co-exist and interact with DM. Early detection of thyroid dysfunction and its treatment can delay the long-term complications of DM. The present study was planned to determine prevalence of thyroid dysfunction in DM patients and therefore to provide the appropriate guidelines.

Methods: The study was cross-sectional. 100 patients were enrolled for the study. Among them 50 were control (non-diabetic) and 50 were cases (diabetic). They were enrolled in the study from medicine outpatient department’s and inpatient department’s according to inclusion and exclusion criteria. Their thyroid profile (free T3, T4 and thyroid stimulating hormone) was done by chemiluminescence assay method.

Results: Results were analyzed by unpaired-t-test. Prevalence of thyroid dysfunction was found significantly high in DM patients. p<0.05 value considered as statistically significant.

Conclusions: Screening for thyroid disease among patients with diabetes mellitus should be routinely performed for early detection and treatment of thyroid dysfunction to delay the complications of diabetes.


Diabetes mellitus, Hyperthyroidism, Hypothyroidism, TSH, T3, T4

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Yadav SC, Saldhana A, Manjumdar B. Status of thyroid profile in type-2 diabetes mellitus. J Nobel Med Coll. 2012;1(1):64-71.

Ramachandran A, Snehalatha C. Current scenario of diabetes in India. J Diabetes. 2009;1:18-28.

Satish R, Mohan V. Diabetes and thyroid diseases. Rev Int J Diabetes Dev Countries. 2003;23:120-3.

Emerging Risk Factors Collaboration, Sarwar N, Gao P, Seshasai SR, Gobin R, Kaptoge S, et al. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Lancet. 2010;375:2215-22.

O’Gara PT, Kushner FG, Ascheim DD, Casey DE Jr, Chung MK, de Lemos JA, et al. 2013 ACCF/AHA Guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2013;127(4):362-425.

Boussageon R, Bejan-Angoulvant T, Saadatian-Elahi M, Lafont S, Bergeonneau C, Kassaï B, et al. Effect of intensive glucose lowering treatment on all-cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials. BMJ. 2011;343:d4169.

Cukierman T. Cognitive decline and dementia in diabetes– Systematic overview of prospective observational studies. Diabetologia. 2005;48(12):2460-9.

Washington RE, Andrews RM, Mutter RL. Emergency Department Visits for Adults with Diabetes, 2010. HCUP Statistical Brief #167. Rockville, MD: Agency for Healthcare Research and Quality;2013.

C-Engin G, Efe B, Akalin A, Kebapci N, Erenoglu E. Thyroid disease in diabetes mellitus. Turk J Endocrinol Metab. 1999;3:119-22.

Gierach M, Gierach J, Junik R. Insulin resistance and thyroid disorders. Endokrynol Pol. 2014;65:70-6.

Wu P. Thyroid diseases and diabetes. Clin Diabetes. 2000;18(1):38.

Tripathi KD. Rssdi Text Book of Diabetes Mellitus. 2nd Edition. New Delhi: Jaypee Brothers; 2008: 258-81, 245-57.

Risérus U, Willett WC, Hu FB. Dietary fats and prevention of type 2 diabetes. Prog Lipid Res. 2009;48(1):44-51.

Lee IM, Shiroma EJ, Lobelo F, Puska P, Blair SN, Katzmarzyk PT; Lancet Physical Activity Series Working Group. Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy. Lancet. 2012;380(9838):219-29.

Palma CC, Pavesi M, Nogueira VG, Clemente EL, Vasconcellos MD, Pereira LC Júnior, et al. Prevalence of thyroid dysfunction in patients with diabetes mellitus. Diabetol Metab Syndr. 2013;5(1):58.

den Hollander JG, Wulkan RW, Mantel MJ, Berghout A. Correlation between severity of thyroid dysfunction and renal function. Clin Endocrinol (Oxf). 2005;62(4):423-7.

Yang GR, Yang JK, Zhang L, An YH, Lu JK. Association between subclinical hypothyroidism and proliferative diabetic retinopathy in type 2 diabetic patients: a case-control study. Tohoku J Exp Med. 2010;222(4):303-10.

Wheeler MH, Lazarus JH. Diseases of the Thyroid. London, Glasgow, Weinheim, New York, Tokyo, Melbourne, Madras: Chapman and Hall Medical, 1994:108-115.

Hage M, Zantout MS, Azar ST. Thyroid disorders and diabetes mellitus: review article. J Thyroid Res. 2011;2011:Article ID 439463:7. doi: 10.4061/2011/439463.

Pasupathi P. Screening for thyroid dysfunction in the diabetic/nondiabetic population. Thyroid Sci. 2008;3(8):CSL-6.

Udiong CE, Udoh AE, Etukudoh ME. Evaluation of thyroid function in diabetes mellitus in Calabar, Nigeria. Indian J Clin Biochem. 2007;22(2):74-8.

Papazafiropoulou A, Sotiropoulos A, Kokolaki A, Kardara M, Stamataki P, Pappas S. Prevalence of thyroid dysfunction among Greek type 2 diabetic patients attending an outpatient clinic. J Clin Med Res. 2010;2(2):75-8.

Akbar DH, Ahmed MM, Al-Mughales J. Thyroid dysfunction and thyroid autoimmunity in Saudi type 2 diabetics. Acta Diabetol. 2006;43(1):14-8.

Radaideh AR, Nusier MK, Amari FL, Bateiha AE, El-Khateeb MS, Naser AS, et al. Thyroid dysfunction in patients with type 2 diabetes mellitus in Jordan. Saudi Med J. 2004;25(8):1046-50.

Flatau E, Trougouboff P, Kaufman N, Reichman N, Luboshitzky R. Prevalence of hypothyroidism and diabetes mellitus in elderly kibbutz members. Eur J Epidemiol. 2000;16(1):43-6.

Díez JJ, Sánchez P, Iglesias P. Prevalence of thyroid dysfunction in patients with type 2 diabetes. Exp Clin Endocrinol Diabetes. 2011;119(4):201-7.

Hollowell JG, Staehling NW, Flanders WD, Hannon WH, Gunter EW, Spencer CA, et al. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab. 2002;87(2):489-99.

Lombardo F, Messina MF, Salzano G, Rabbone I, Lo Presti D, Calcaterra V, et al. Prevalence, presentation and clinical evolution of Graves’ disease in children and adolescents with type 1 diabetes mellitus. Horm Res Paediatr. 2011;76(4):221-5.

Celani MF, Bonati ME, Stucci N. Prevalence of abnormal thyrotropin concentrations measured by a sensitive assay in patients with type 2 diabetes mellitus. Diabetes Res. 1994;27(1):15-25.

Wang C. The relationship between Type 2 diabetes mellitus and related thyroid diseases. J Diabetes Res. 2013;2013:390534.

Tunbridge WM, Evered DC, Hall R, Appleton D, Brewis M, Clark F, et al. The spectrum of thyroid disease in a community: the Whickham survey. Clin Endocrinol (Oxf). 1977;7(6):481-93.

Perros P, McCrimmon RJ, Shaw G, Frier BM. Frequency of thyroid dysfunction in diabetic patients: value of annual screening. Diabet Med. 1995;12(7):622-7.

Canaris GJ, Manowitz NR, Mayor G, Ridgway EC. The Colorado thyroid disease prevalence study. Arch Intern Med. 2000;160(4):526-34.

Gupta S, Verma M, Gupta AK, Kaur A, Kaur V, Singh K. Are we using thyroid function tests appropriately? Indian J Clin Biochem. 2011;26:178-81.

Ladenson PW, Singer PA, Ain KB, Bagchi N, Bigos ST, Levy EG, et al. American Thyroid Association guidelines for detection of thyroid dysfunction. Arch Intern Med. 2000;160(11):1573-5.