Drug utilization pattern of antidiabetic agents in a tertiary care hospital of western Odisha, India
DOI:
https://doi.org/10.18203/2319-2003.ijbcp20163265Keywords:
Defined daily dose, Insulin, Metformin, SulfonylureasAbstract
Background: A changing life style in developing countries like India has increased the statistical figure of diabetes mellitus even among rural populations and younger age groups. Prevalence rate of diabetes in Odisha is about 10%. There is intensive polypharmacy as regards the treatment of diabetes mellitus which is not only affecting the quality of life of patients adversely by producing side effects including hypoglycemia but also taking a toll on the financial state of the poor people. With this background, this study was conducted to evaluate the drug utilization pattern of antidiabetic agents to facilitate rational use of drugs in this condition.
Methods: This observational study was conducted in 230 patients for a period of 2 months in the department of general medicine at V. S. S. Institute of Medical Sciences and Research, Burla. After taking informed consent, the patient’s case records, prescriptions, investigational reports and co - morbidities were evaluated.
Results: In our study, insulin was found to be the most commonly used antidiabetic agent both during hospital stay (80%) and also at the time of discharge (60%). Metformin with sulfonylurea was the most frequently prescribed oral anti diabetic combination in 9.5% of patients. Average cost of insulin therapy was rs. 80 per patient per month and of oral antidiabetic drug was rs. 45.66 per patient per month during hospital stay.
Conclusions: The prescribing trend has been monotherapy with insulin followed by oral antidiabetic drugs in the form of glimepiride and metformin combination.
References
Sahoo P. National summit on NCDs: Orissa’s contribution and initiations appreciated programme to be extended to 4 more districts Bhubaneshwar; 2011. Available at http://www.odisha.gov.in/samachar/2011/Sep/data/02-09-2011/NCDs-portal.pdf. Accessed on 25 June 2016.
Population of Orissa [Internet] 2015. Available from: www.indiaonlinepages.com/population/orissa-population.html. Accessed on 25 June 2016.
The certificate course in evidence based diabetes management CCEBDM is based on the principles of evidence based medicine. Available at ccebdm.org/news.php.
National Programme for prevention and control of Cancer, Diabetes, CVD and Stroke. (NPCDCS) and National Programme for Health Care of Elderly (NPHCE). Progress report of Odisha; 2013:2.
Annual report to the people on health. Government of India, Ministry of Health and Family Welfare. 2011:9 Available at http://mohfw.nic.in/WriteReadData/l892s/26697288736960144509 Annual Report to the People on Health.pdf. Accessed on 25 June 2016.
WHO collaborating centre for drug statistics methodology. ATC index with DDDs. Oslo: WHO Collaborating Centre for Drug Statistics Methodology; 2002.
Patel B, Oza B, Patel KP, Malhotra SD, Patel VJ. Pattern of antidiabetic drugs use in type-2 diabetic patients in a medicine outpatient clinic of a tertiary care teaching hospital. Int J Basic Clin Pharmacol. 2013;2(4):485-91.
Sudha V, Shukla P, Patidar P, Bafna R, Jain S. Prescribing pattern of antidiabetic drugs in Indore City Hospital Indian. Journal of Pharmaceutical Sciences. 2008;70(5):637-40.
Boccuzzi SJ, Wogen J, Fox J, Sung JC, Shah AB, Kim J. Utilization of oral hypoglycemic agents in a drug-insured U.S. population. Diabetes Care. 2004;24(8):1411-5.
Johnson JA, Pohar SL, Secnik K. Utilization of diabetes medication and cost of testing supplies in Saskatchewan 2001. BMC Health Serv Res. 2006;6:159.
Yurgin N, Secnik K, Lage MJ. Antidiabetic prescriptions and glycemic control in German patients with type 2 diabetes mellitus: a retrospective database study. Clin Ther. 2007;29(2):316-25.
Jenny L, Arifulla M, Sreedharan J, Muttappallymyalil J, Das R. Age and gender-based utilization pattern of antidiabetic drugs in Ajman, UAE. Malay J Pharm Sci. 2012;10(1):79-85.
Sultana G, Kapur P, Aqil M, Alam MS, Pillai KK. Drug utilization of oral hypoglycemic agents in a university teaching hospital in India. J Clin Pharm Ther. 2010;35:267-77.
Krentz AJ, Bailey CJ. Oral antidiabetic agents: current role in type II diabetes mellitus. Drugs. 2005;65(3):385-411.
Dills DG, Schneider J. Clinical evaluation of glimepiride versus glyburide in NIDDM in a double- blind comparative study. Glimepiride/Glyburide Research Group. Horm Metab Res. 1996;28(9):426-9.
Kannan, Arshad, Kumar S. A study on drug utilization of oral hypoglycemic agents in type-2 diabetic patients. Asian J Pharm Clin Res. 2011;4(4):60-4.
Acharya KG, Shah KN, Solanki ND, Rana DA. Evaluation of antidiabetic prescription cost and adherence to treatment guidelines: a prospective, cross-sectional study at a tertiary care teaching hospital. J Basic Clin Pharm. 2013;4(4):82-8.
Abdi SA, Churi S, Kumar YS. Study of drug utilization pattern of antihyperglycemic agents in a south indian tertiary care teaching hospital. Indian J Pharmacol. 2012;44(2):210-4.