The effect of calcium channel blockers against scopolamine induced cognitive impairment and oxidative stress

D. Seshadri Sekhar, B. K. Shwetha, B. Haimavathi, P. Vikram


Background: the present work has been planned to find out the effect of calcium channel blockers on learning and memory. there are numerous reports indicating that calcium channel blockers (CCBS) impair memory and learning and on the other side there are reports indicating that CCBS improve memory and learning .This contradictory reports led us to investigate the effect of CCBS on memory and learning by taking three different types of calcium channel blockers verapamil, nimodipine and diltiazem.

Methods: The methods used were elevated plus maze and novel recognition object tests. Ten groups of animals were treated with CCBS and scopolamine. Both prophylactic and curative studies were carried out.

Results: It was evident from our studies that the CCBS effectively antagonized the scopolamine induced cognitive impairment in the paradiagms studied. The inflex ratio and novel object discrimination index also increased indicating decrease in the trancefer latencies. CCBS showed good protection against scopolamine induced cognitive.

Conclusions: In our Studies we observed that verapamil was good in prophylactic studies and diltiazem in curative studies.


CCBS, Learning and memory, Scopolamine, Amnesia, Elevated plus maze, Novel object recognition test

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