Prevalence and antimicrobial susceptibility pattern of methicillin resistant Staphylococcus aureus in Silchar Medical College and Hospital, Assam, India

Devarsi Choudhury, Pinaki Chakravarty


Background: Methicillin resistant staphylococcus aureus (MRSA) strains, usually resistant to several antibiotics, is a cause of concern in many countries. This study determines the prevalence and antimicrobial susceptibility pattern of MRSA in Silchar Medical College and Hospital (SMCH), Assam.

Methods: This retrospective was conducted from January 2014 to June 2015 (1 year and 6 months) in SMCH, Assam. Four samples seen were blood, urine, pus and ear swab. Screening and confirmation of MRSA isolates were done by standard methods recommended by Clinical and laboratory standards institute (CLSI). Staphylococcus aureus strains were tested for Methicillin resistance by using oxacillin/ cefoxitin. The antibiotic susceptibility pattern of all MRSA strain was determined by Kirby-Bauer disc diffusion method.

Results: Out of 724 positive staphylococcus strains, MRSA accounted for 311 cases (42.96%). Highest percentage of MRSA cases were from blood culture (61.68%). MRSA cases even showed resistance to other antibiotics like cefuroxime, amoxicillin and clavulanic acid, getamicin, levofloxacin, ciprofloxacin, ceftriaxone, nitrofurantoin, amikacin, and vancomycin. 59.50% cases of MRSA cases showed resistance to cefuroxime. Even Methicillin sensitive strains of staphylococcus Aureus (MSSA) showed resistance to antibiotics like cefuroxime and amoxicillin and clavulanic acid.

Conclusions: The worst feature of MRSA is simultaneous drug resistance to many antibiotics. Measures preventing the spread of MRSA are to be enhanced as fewer options are available for treating MRSA. Hospital guidelines for proper antibiotics usage should be followed.


MRSA, Staphylococcus aureus, Resistance, Susceptibility, Cefuroxime

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