Prospective, randomized, double blind, placebo controlled clinical study to different doses of ketamine for prevention of shivering during spinal anaesthesia

Authors

  • Kanchan R. Rupwate Department of Anaesthesiology, L.T.M.M.C and L.T.M.G.H, Sion, Mumbai, India
  • Swarda K. Pardeshi Department of Anaesthesiology, L.T.M.M.C and L.T.M.G.H, Sion, Mumbai, India
  • Bharati A. Tendolkar Department of Anaesthesiology, L.T.M.M.C and L.T.M.G.H, Sion, Mumbai, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20162816

Keywords:

Ketamine, Shivering, Perioperative, Shivering score, Spinal anaesthesia

Abstract

Background: Ketamine has better effect than other drugs like pethidine, fentanyl, clonidine, tramadol, midazolam in prevention of shivering during anaesthesia and has a role in thermoregulation by different means. The objective of this study was to evaluate the safety, efficacy of Ketamine injection and to compare the different doses (0.25 mg/kg and 0.5 mg/kg) of inj. Ketamine in prevention of shivering in operative patients under spinal anaesthesia.

Methods: The present study was a prospective, randomized, double blinded and clinical study conducted in L.T.M.M.C & L.T.M.G.H, Mumbai, India during January 2012 to September 2013. 120 patients with American Society of Anesthesiologist (ASA) physical status of I or II, between the age of 18 – 65 years of either sex and height 150-170 cms were randomly selected and included in the study as per eligibility.

Results: The study suggests that prophylactic administration of injection Ketamine at doses of 0.25 mg/kg and 0.5 mg/kg was producing a significant antishivering effect but an incidence of sedation and hallucination was observed in the Ketamine 0.5 mg/kg receiving group throughout the perioperative period.

Conclusions: From this study we can conclude that prophylactic dose of Ketamine 0.25 mg/kg i.v. has lesser side effects comparison to Ketamine 0.5 mg/kg i.v. in prevention of shivering in patients, undergoing surgical procedure under spinal anaesthesia.

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Published

2017-01-10

How to Cite

Rupwate, K. R., Pardeshi, S. K., & Tendolkar, B. A. (2017). Prospective, randomized, double blind, placebo controlled clinical study to different doses of ketamine for prevention of shivering during spinal anaesthesia. International Journal of Basic & Clinical Pharmacology, 5(5), 1866–1876. https://doi.org/10.18203/2319-2003.ijbcp20162816

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Original Research Articles