Analgesic activity of ethanolic extract of leaves of Nyctanthes arbor-tristis linn on experimental animal models

Authors

  • Pallavi Bordoloi Department of Pharmacology, Assam Medical College, Dibrugarh, Assam, India
  • Tarali Devi Department of Pharmacology, Assam Medical College, Dibrugarh, Assam, India
  • Mangala Lahkar Department of Pharmacology, Guwahati Medical College, Guwahati, Assam, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20164131

Keywords:

Analgesic, Flavonoids, Nyctanthes arbortristis

Abstract

Background: The present study has been undertaken to evaluate the pharmacological efficacy of ethanolic extract of leaves of Nyctanthes arbor-tristis (EENA) LINN as an analgesic agent in comparison with standard non-steroidal anti-inflammatory agents.

Methods: The extract was prepared by soxhlet method and acute toxicity test was performed as per OECD guidelines. The peripheral analgesic activity was assessed using acetic acid induced writhing method. The central analgesic activity was assessed using tail-flick method.

Results: It has been shown that EENA 400mg/kg and aspirin 100mg/kg significantly increased the pain threshold as assessed by increase in the latency period or basal reaction time. EENA (200mg, 400 mg/kg) and aspirin 100 mg/kg also significantly reduced acetic acid induced writhing response showing peripheral analgesic activity.

Conclusions: Since prostaglandins are involved in the pain perception and are inhibited by flavonoids, it could be suggested that the analgesic effect of Nyctanthes arbortristis might be due to its inhibitory action on PG biosynthesis.

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Published

2016-12-21

How to Cite

Bordoloi, P., Devi, T., & Lahkar, M. (2016). Analgesic activity of ethanolic extract of leaves of Nyctanthes arbor-tristis linn on experimental animal models. International Journal of Basic & Clinical Pharmacology, 5(6), 2598–2601. https://doi.org/10.18203/2319-2003.ijbcp20164131

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Original Research Articles