Hand tremor possibly induced by interaction of risperidone and lithium in a case of bipolar disorder with schizophrenia: a case report

Authors

  • Santanu Munshi Department of Clinical and Experimental Pharmacology, Calcutta School of Tropical Medicine, Kolkata, India
  • Ranjita Santra (Dhali) Department of Clinical and Experimental Pharmacology, Calcutta School of Tropical Medicine, Kolkata, India
  • Indranil Saha Department of Psychiatry, Institute of Psychiatry Kolkata, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20162493

Keywords:

Drug induced tremors, Lithium, Risperidone, Drug interaction, Bipolar disorder

Abstract

Drug-induced movement disorders possess a varied presentation and pose a challenging task for the physicians to diagnose such cases. A middle-aged woman with bipolar disorder comorbid with schizophrenia was under treatment with lithium carbonate, risperidone, sodium valproate, trihexiphenidyl tablets on a daily basis for two years. She experienced bilateral tremors of the hands which were present at rest and exacerbated by mental activity, when under observation and during voluntarily initiated activity. There were no associated extrapyramidal or cerebellar signs. The tremors persisted after withdrawal of sodium valproate and trihexiphenidyl, but disappeared completely after risperidone was stopped but lithium carbonate intake continued in an uninterrupted manner. Investigations did not reveal any positive finding. Hence, drug interaction may possibly be the offender for tremors in this case.

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Published

2017-01-05

How to Cite

Munshi, S., Santra (Dhali), R., & Saha, I. (2017). Hand tremor possibly induced by interaction of risperidone and lithium in a case of bipolar disorder with schizophrenia: a case report. International Journal of Basic & Clinical Pharmacology, 5(4), 1684–1686. https://doi.org/10.18203/2319-2003.ijbcp20162493

Issue

Section

Case Reports