Effects of carbonated beverage and fruit juice on salivary pH among children in orphanage of Bareilly city: an in vivo study
DOI:
https://doi.org/10.18203/2319-2003.ijbcp20230390Keywords:
Carbonated beverage, Fruit juice, Orphaned childrenAbstract
Background: High degree of urbanization and economic development have resulted in rapid changes in diet and lifestyles, because of which there is a tremendous increase in prevalence of dental caries in developing countries. The aim of the study is to assess the acidogenic potential of commonly consumed carbonated beverage and commercially available fruit juice at various time intervals among orphan children.
Methods: This is an in vivo study in which 60 orphan children were included. Two beverage groups (carbonated beverage and fruit juice) were tested for salivary pH before having respective drinks (baseline) and after having drinks at specific time intervals (immediately after, after 15 min and 30 min). Intra-group and inter-group comparisons were done using Friedman test and Mann Whitney U test.
Results: Both the groups showed decrease in salivary pH after consumption and recovery of salivary pH to baseline value after 30 min.
Conclusions: Beverages produce a remarkable drop in the salivary pH as they contain organic acids and sugars but saliva by virtue of its buffering capacity nullifies this effect and after some time it comes to normal.
Metrics
References
Stone HH, Kolb LD, Geheber CE, Currie CA. Treatment of surgical infections with Tobramycin. Am Surg. 1975;41:301.
Nagai J, Takano M. Molecular aspects of renal handling of aminoglycosides and strategies for preventing the nephrotoxicity. Drug Metab Pharmacokineti. 2004;19:159-70.
Lauren G, Kishore BK, Tulkens PM. Aminoglycoside-induced renal phospholipidosis and nephrotoxicity. Biochem. Pharmacol. 1990;40:2383-92.
Leehey DJ, Braun BI, Tholl DA, Chung LS, Gross CA, Roback JA, et al. Can pharmacokinetic dosing decrease nephrotoxicity associated with aminoglycoside therapy. J Am Soc Nephrol. 1993;4:81-90.
Gilbert DN. Aminoglycosides. In: Mandell GL, Bennett JE, Dolin R, eds. Principles and practice of infectious diseases. 4th ed. New York: Churchill Livingstone; 1995:279-306.
Lott RS, Hayton WL. Estimation of creatinine clearance from serum creatinine concentration. Drug Intell Clin Pharm. 1978;12:140-50.
Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31-41.
Martínez-Salgado C, López-Hernández FJ, López-Novoa JM. Glomerular nephrotoxicity of aminoglycosides. Toxicol Appl Pharmacol. 2007;223(1):86-98.
Ballesteros J, Northland R, Wolff M. Gentamicin and Amikacin nephrotoxicity: comparative study in patients with initially normal renal function. Rev Med Chil. 1989;117(1):10-7.
Sweileh WM. A prospective comparative study of gentamicin and Amikacin induced nephrotoxicity in patients with normal baseline renal function. Fundam Clin Pharmacol. 2009;23(4):515-20.
Hadjipour N. Histopathological comparision of Gentamicin and Amikacin nephrotoxicity in rabbits. Journal of Animal and Veterinary Advances. 2011;10(8):1003-6.
De Broe ME, Paulus GJ, Verpooten GA, Roels F, Buyssens N, Wedeen R, et al. Early effects of Gentamicin, Tobramycin, and Amikacin on the human kidney. Kidney International. 1984;25:643-52.
Bonadio M, Maccanti O, Giovannini L, Bertelli AA, Scalori V, Alessandrì MG, et al. Comparative nephrotoxicity and tissue accumulation of dactimicin, Amikacin and Gentamicin. Drugs Exp Clin Res. 1987;13(12):747-50.
Gilbert DN, Plamp C, Starr P, Bennett WM, Houghton DC, Porter AG. Comparative nephrotoxicity of Gentamicin and Tobramycinin Rats. Antimicrobial agents and chemotherapy, 1978;34-40.
French MA, Cerra FB, Plaut ME, Schentag JJ. Amikacin and gentamicin accumulation pharmacokinetics and nephrotoxicity in critically ill patients. Antimicrob Agents Chemother. 1981;19(1):147-52.