Effect of tylophora asthmatica on hepatotoxicity induced by antitubercular drugs in albino rats


  • Ajay R. Chandrakapure Department of Pharmacology, IIMSR, Warudi, Jalna, Maharashtra, India
  • Vijay M. Motghare Department of Pharmacology, GMC, Nagpur, Maharshtra, India
  • Sudhir L. Padwal Department of Pharmacology, SRTRMCH, Ambajogai, Maharashtra, India
  • Avinash V. Turankar Department of Pharmacology, GMC, Nagpur, Maharshtra, India
  • Vinod S. Deshmukh Department of Pharmacology,GMC, Latur, Maharashtra, India




Tylophora asthmatica, Antitubercular drugs, Hepatotoxicity, ALT, AST, Bilirubin


Background: The burden of metabolism and exposure to dangerous chemicals make liver vulnerable to variety of disorders like acute or chronic inflammation, toxin/ drug related hepatitis or cirrhosis. Tuberculosis is a common problem in India and worldwide. Drug induced liver injury (DILI) is a problem of increasing significance, but has been a long standing concern in treatment of tuberculous (TB) infection. Several studies have revealed that, tylophora asthmatica (Burnf.) Merill. (Family: asclepidaceae) commonly known as antmul possess hepatoprotective property. There is less scientific work regarding the effect of Tylophora asthmatica on hepatotoxicity induced by antitubercular drugs, hence the present study was carried out with the aim of evaluating the effect of tylophora asthmatica on antitubercular drug induced hepatotoxicity in albino rats.

Methods: Total 24 Albino rats weighing about 150-200 grams were divided in four groups, 6 animals in each group. In the study, antitubercular drugs: INH (50 mg/kg) and rifampicin (50 mg/kg), test drug: aqueous extract of tylophora asthmatica doses (200 mg/kg and 300 mg/kg) were used. Drugs were given by oral route for 14 days. Biochemical tests for Sr. ALT, AST, bilirubin (total and direct) and histopathological examination of liver was done.

Results: Tylophora asthmatica treated group had no significant rise in values of Sr.ALT, AST, bilirubin (total and direct) and also there were no significant histopathological changes in this group, indicating hepatoprotective effect of tylophora asthmatica.

Conclusions: It was concluded that tylophora asthmatica has hepatoprotective activity in antitubercular drug induced hepatotoxicity.


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How to Cite

Chandrakapure, A. R., Motghare, V. M., Padwal, S. L., Turankar, A. V., & Deshmukh, V. S. (2017). Effect of tylophora asthmatica on hepatotoxicity induced by antitubercular drugs in albino rats. International Journal of Basic & Clinical Pharmacology, 5(4), 1402–1407. https://doi.org/10.18203/2319-2003.ijbcp20162442



Original Research Articles