Anti-dyslipidemic activity of acacia tortilis seed extract in alloxan-induced diabetic rats

Authors

  • Neeraj Kumar Agrawal Department of Pharmacology, Himalayan Institute of Medical Science, SRH University, Dehradun, Uttarakhand, India
  • Suyog Sindhu Department of Pharmacology, MRA Medical College, Ambedkarnagar, Uttar Pradesh, India
  • Nitin Kothari Department of Pharmacology, Pacific Medical College, Udaipur, Rajasthan, India
  • Shruti Chandra Department of Pharmacology, JIIU’s Indian Institute of Medical Sciences and Research, Warudi, Badnapur, Jalna, Maharashtra, India
  • Gini Garima Department of Biochemistry, Shaheed Hasan Khan Mewati Govt Medical College, Nalhar, Mewat, Haryana, India
  • Uma Gupta PhD Life Science, University of Rajasthan, Jaipur, Rajasthan, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20162440

Keywords:

Anti-dyslipidemic activity, Acacia tortilis, Alloxan-induced diabetic rats

Abstract

Background: The present study was carried out to evaluate the anti-dyslipidemic activities of seed extract of acacia tortilis (ATE) in alloxan inducd diabetic rats.

Methods: The Rats were divided into five groups of six animals each. Groups I and II received normal saline, group III received ATE in dose of 100 mg/kg body weight, group IV received ATE in dose of 200 mg/kg b.w.; and group V received standard drug pioglitazone dose 3 mg/kg b.w. Drugs were administered orally once a day for 30 days. At the end of 0th, 10th, 20th  and 30th day, blood was collected to analyse serum glucose, serum insulin, total cholesterol (TC), serum phospholipid (PL), serum triglyceride (TG), Free fatty acids (FFA) and High density lipoprotein (HDL).

Results: The results has been showed that ATE in above doses significantly increase the serum insulin and HDL level but significantly decreased the elevated level of TC, PL, TG , FFA, LDL and VLDL. It also decreased the atherogenic index and coronary risk index level significantly which was comparable with the pioglitazone.

Conclusions: It is concluded that the seed extract of acacia tortilis at the dose of 100 and 200 mg/kg body weight produced significant anti-dyslipidemic activity in alloxan-induced diabetic rats.

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Published

2017-01-05

How to Cite

Agrawal, N. K., Sindhu, S., Kothari, N., Chandra, S., Garima, G., & Gupta, U. (2017). Anti-dyslipidemic activity of acacia tortilis seed extract in alloxan-induced diabetic rats. International Journal of Basic & Clinical Pharmacology, 5(4), 1389–1396. https://doi.org/10.18203/2319-2003.ijbcp20162440

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Original Research Articles