Anti-dyslipidemic activity of acacia tortilis seed extract in alloxan-induced diabetic rats

Neeraj Kumar Agrawal; Suyog Sindhu; Nitin Kothari; Shruti Chandra; Gini Garima; Uma Gupta

doi:10.18203/2319-2003.ijbcp20162440

Authors

Neeraj Kumar Agrawal Department of Pharmacology, Himalayan Institute of Medical Science, SRH University, Dehradun, Uttarakhand, India
Suyog Sindhu Department of Pharmacology, MRA Medical College, Ambedkarnagar, Uttar Pradesh, India
Nitin Kothari Department of Pharmacology, Pacific Medical College, Udaipur, Rajasthan, India
Shruti Chandra Department of Pharmacology, JIIU’s Indian Institute of Medical Sciences and Research, Warudi, Badnapur, Jalna, Maharashtra, India
Gini Garima Department of Biochemistry, Shaheed Hasan Khan Mewati Govt Medical College, Nalhar, Mewat, Haryana, India
Uma Gupta PhD Life Science, University of Rajasthan, Jaipur, Rajasthan, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20162440

Keywords:

Anti-dyslipidemic activity, Acacia tortilis, Alloxan-induced diabetic rats

Abstract

Background: The present study was carried out to evaluate the anti-dyslipidemic activities of seed extract of acacia tortilis (ATE) in alloxan inducd diabetic rats.

Methods: The Rats were divided into five groups of six animals each. Groups I and II received normal saline, group III received ATE in dose of 100 mg/kg body weight, group IV received ATE in dose of 200 mg/kg b.w.; and group V received standard drug pioglitazone dose 3 mg/kg b.w. Drugs were administered orally once a day for 30 days. At the end of 0^th, 10^th, 20^th and 30^th day, blood was collected to analyse serum glucose, serum insulin, total cholesterol (TC), serum phospholipid (PL), serum triglyceride (TG), Free fatty acids (FFA) and High density lipoprotein (HDL).

Results: The results has been showed that ATE in above doses significantly increase the serum insulin and HDL level but significantly decreased the elevated level of TC, PL, TG , FFA, LDL and VLDL. It also decreased the atherogenic index and coronary risk index level significantly which was comparable with the pioglitazone.

Conclusions: It is concluded that the seed extract of acacia tortilis at the dose of 100 and 200 mg/kg body weight produced significant anti-dyslipidemic activity in alloxan-induced diabetic rats.

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