DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20220407

Evaluation of anti-thyroid activity of Fragariavesca in male rats

Venkata Ramana Y., Rajesh Kumar, Hema Sankar C., Prashanth G., Sadgunottama Goud

Abstract


Background: A number of pharmacological agents are available for use as antithyroid agents. Fragariavesca a plant extract widely available can be evaluate for its antithyroid activity.

Methods: Fragariavesca can be used as anti-inflammatory, anti-microbial, anti-allergic and anti-diabetic. This plants extract is also shown antithyroid activity. Hyperthyroidism induced rats were experimented by administering thyroxine orally for 14 days. Hyperthyroid wistar male rats were treated with oral doses of 2 mg, 4 mg and 6 mg of Fragariavesca extract for a period of 21 days. Methimazole 0.04% w/v for 21 days was used as the standard.

Results: This study had shown that T3 and T4levels successfully reduced with increase in the dose of Fragariavesca extract when compare to the standard methimazole.

Conclusions: The antithyroid activity of Fragariavesca is clearly evident to decrease the levels of T3 and T4 levels. Further molecular studies can be conducted to determine the exact mechanism of action for its anti-thyroid activity.


Keywords


Thyroxine, Hyperthyroidism, Fragariavesca, Plant extract

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