Study on drug profile used in common pregnancy influenced issues and its complications

Semmalar G. V., Kaviya Anisha S. J., Terry Sheetal B., Saravanakumar R. T., Latha K.


Background: Pregnancy influenced issues are common among pregnant women treated by medications that causes complication in mother and fetus. The study aims to identify patients with pregnancy influenced issues like gestational diabetes mellitus, gestational hypertension, gastroesophageal reflux disease and anaemia. To assess the drug used pattern along with antibiotic therapy and to observe the above disease related complications.

Methods: A hospital based prospective observational study was conducted at department of obstetrics and gynecology in Rajah Muthiah Medical College and Hospital. Totally 100 patients enrolled and data was collected using data collection form.

Results: Out of 100 patients, high prevalence occurred in 26-30 years of age. Primarily gestational hypertension (39%), treated with Tab. Labetatol and complications were premature delivery, low birth weight. Anaemia (25%) cases treated with Tab. Ferrous sulphate, Iron sucrose and Folic Acid, Preterm delivery as complication. Gestational diabetes mellitus (18%) treated with Metformin and Human Insulin and complications were preterm delivery, maternal obesity, increased child weight. GERD (8%) treated with Pantoprazole, Ondansetron, Bifilac and complications were weight loss, dehydration, low birth weight. In pre-operative cases, 79% received antibiotics as monotherapy and 21% as dual therapy. In post-operative cases, 41% received antibiotics as monotherapy and 59% as dual therapy. Metronidazole (95%) given in both post and pre- operative conditions.

Conclusions: The present study provides valuable insight about the overall drugs used in pregnancy related diseases and complications arise. We hope our data will make necessary recommendations to all health care professionals and pregnant women to ensure all pregnancy related safety measures were taken.


Gestational hypertension, Gestational diabetes mellitus, Gastroesophageal reflux disease, Anaemia, Antibiotics, Complications

Full Text:



Mammaro A, Carrara S, Cavaliere A, Ermito S, Dinatale A, Pappalardo EM, et al. Hypertensive disorders of pregnancy. J Prenat Med. 2009;3(1):1-5.

Gestational Diabetes Mellitus. Available at:

Sifakis S, Pharmakides G. Anemia in pregnancy. Ann N Y Acad Sci. 2000;900:125-36.

Goral V. Ideal Approach to Gastroesophageal Reflux in Pregnancy. Mathews J Gastroenterol Hepatol. 2018;3(1):11.

Mustafa R, Ahmed S, Gupta A, Venuto RC. A comprehensive review of hypertension in pregnancy. J Pregnancy. 2012;2012:105918.

Plouin PF, Bréart G, Maillard F, Papiernik E, Relier JP. Maternal effects and perinatal safety of labetalol in the treatment of hypertension in pregnancy. Arch Mal Coeur Vaiss. 1987;80(6):952-5.

Gao Y, Sheng C, Xie RH, Sun W, Asztalos E, Moddemann D, et al. New Perspective on Impact of Folic Acid Supplementation during Pregnancy on Neurodevelopment/Autism in the Offspring Children - A Systematic Review. PLoS One. 2016;11(11):e0165626.

Milman N. Oral iron prophylaxis in pregnancy: not too little and not too much! J Pregnancy. 2012;2012:514345.

Priya G, Kalra S. Metformin in the management of diabetes during pregnancy and lactation. Drugs Context. 2018;7:212523.

Law R, Maltepe C, Bozzo P, Einarson A. Treatment of heartburn and acid reflux associated with nausea and vomiting during pregnancy. Can Fam Physician. 2010;56(2):143-4.

Kattah AG, Garovic VD. The management of hypertension in pregnancy. Adv Chronic Kidney Dis. 2013;20(3):229-39.

Bhattacharyya A, Brown S, Hughes S, Vice PA. Insulin lispro and regular insulin in pregnancy. QJM. 2001;94(5):255-60.

Kriplani A, Mahey R, Dash BB, Kulshreshta V, Agarwal N, Bhatla N. Intravenous iron sucrose therapy for moderate to severe anaemia in pregnancy. Indian J Med Res. 2013;138(1):78-82.

Zhang J, Villar J, Sun W, Merialdi M, Abdel-Aleem H, Mathai M, et al. Blood pressure dynamics during pregnancy and spontaneous preterm birth. Am J Obstet Gynecol. 2007;197(2):162.e1-6.

Barton JR, O'brien JM, Bergauer NK, Jacques DL, Sibai BM. Mild gestational hypertension remote from term: progression and outcome. Am J Obstet Gynecol. 2001;184(5):979-83.

Harper LM, Tita A, Biggio JR. The institute of medicine guidelines for gestational weight gain after a diagnosis of gestational diabetes and pregnancy outcomes. Am J Perinatol. 2015;32(3):239-46.

Yi SW, Han YJ, Ohrr H. Anemia before pregnancy and risk of preterm birth, low birth weight and small-for-gestational-age birth in Korean women. Eur J Clin Nutr. 2013;67:337–42.

Jennings LK, Krywko DM. Hyperemesis Gravidarum. 2021. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021.

Hyer S, Balani J, Shehata H. Metformin in Pregnancy: Mechanisms and Clinical Applications. Int J Mol Sci. 2018;19(7):1954.

Martinez de Tejada B. Antibiotic use and misuse during pregnancy and delivery: benefits and risks. Int J Environ Res Public Health. 2014;11(8):7993-8009.

Sheehy O, Santos F, Ferreira E, Bérard A. “The Use of Metronidazole During Pregnancy: A Review of Evidence”, Current Drug Safety. 2015;10(2);15-9.