Study on antihyperglycemic effect of bromocriptine in dexamethasone induced hyperglycemic wistar rats

Authors

  • Rekha M. B. Department of Pharmacology, RRMCH, Bangalore, Karnataka, India
  • Basavaraj Bhandare Department of Pharmacology, RRMCH, Bangalore, Karnataka, India
  • Satyanarayana V. Department of Pharmacology, RRMCH, Bangalore, Karnataka, India
  • Hemamalini M. B. Department of Pharmacology, RRMCH, Bangalore, Karnataka, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20212081

Keywords:

Bromocriptine, Wistar rats, Diabetes mellitus, Metformin

Abstract

Background: Diabetes mellitus is a chronic metabolic disorder that develops due to insulin deficiency or insulin resistance. Recent animal and human studies have reported bromocriptine to be effective in the management of type 2 diabetes mellitus. The present study was done to evaluate the antihyperglycemic effect of bromocriptine in dexamethasone induced hyperglycemic rats.

Methods: Male wistar rats were used and divided into 5 groups. Dexamethosone was used to induce hyperglycemia in group B-E. Group A was the untreated control group, group B was the standard control group, group C was the oral 10 mg/kg of bromocriptine dissolved in 0.9% normal saline, group D was the oral 20 mg/kg metformin dissolved in 0.9% normal saline, group E was the oral 10 mg/kg bromocriptine+20 mg/kg metformin dissolved in 0.9% normal saline. Fasting blood glucose, post prandial blood glucose and body weight was estimated on day 1, 15, 30.

Results: It was seen that dexamethasone induced hyperglycemia and increase in body weight in male wistar rats, which were significantly controlled by oral bromocriptine and bromocriptine with metformin combination.

Conclusions: Results obtained from this study showed that bromocriptine can be a promising drug with novel mechanism to treat type 2 diabetes mellitus.

Author Biography

Rekha M. B., Department of Pharmacology, RRMCH, Bangalore, Karnataka, India

Associate professor

Dept of pharmacology

RRMCH

Bengaluru

References

International Diabetes Federation. IDF Diabetes Atlas, 8th ed. Brussels, Belgium: International Diabetes Federation; 2017

Cho NH, Shaw JE, Karuranga S, Huang Y, Fernandes JDR, Ohlrogge AW. IDF Diabetes Atlas: global estimates of diabetes prevalence for 2017 and projection for 2045. Diabetes Res Clin Pract. 2018:138:271-81.

Shivaprasad C, Kalra S. Bromocriptine in type 2 diabetes mellitus. Ind J Endocr Metabol. 2011:15(1):17-24.

Maharajan R, Gupta K, Kapoor V. A systematic account of pathogenesis, diagnosis and pharmacotherapy of metabolic syndrome. Things we need to know. Int J Pharmacol. 2010:6(4):338-45.

Norris SL, Zhang X, Avanell A, Gregg E, Schmid CH, Kim C, et al. Efficacy of pharmacotherapy for weight loss in adults with type-2 diabetes mellitus: a meta-analysis. Arch Intern Med. 2004:164(13):1395-404.

Kerry JL, Timpe EM, Petkewicz KA. Bromocriptine mesylate for glycemic management in type-2 diabetes mellitus. Ann Pharmacother. 2010;44(11):1777-85.

Via MA, Chandra H, Araki T, Potenza MV, Skamagas M. Bromocriptine approved as the first medication to target dopamine activity to improve glycemic control in patients with type-2 diabetes. Diabetes Metab Syndr Obes. 2010;3:43-8.

Defronzo RA. Bromocriptine: A sympatholytic D2 dopamine agonist for the treatment of type2 diabetes. Diabet Care. 2011;34(4):789-94.

Powers AC, D’Alessio D. Endocrine pancreas and pharmacotherapy of diabetes mellitus and hypoglycemia. Goodman and Gilman’s the pharmacological basis of therapeutics. New York: Brunton Medical; 2018: 1237-73.

Cincotta AH, Meier AH. Bromocriptine reduces body weight and improves glucose tolerance in obese subjects. Diabetes Care. 1996;19(6):667-70.

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Published

2021-05-25

How to Cite

M. B., R., Bhandare, B., V., S., & M. B., H. (2021). Study on antihyperglycemic effect of bromocriptine in dexamethasone induced hyperglycemic wistar rats. International Journal of Basic & Clinical Pharmacology, 10(6), 699–703. https://doi.org/10.18203/2319-2003.ijbcp20212081

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Section

Original Research Articles