Measurement of antibiotic consumption in surgical ward of a tertiary care hospital

Authors

  • Rashmi R. Pujari Department of Pharmacology, Veer Surendra Sai Institute of Medical Science and Research, Burla, Sambalpur, Odisha, India
  • Bhabagrahi Rath Department of Pharmacology, Veer Surendra Sai Institute of Medical Science and Research, Burla, Sambalpur, Odisha, India
  • Tapan Kumar Nayak Department of Surgery, Veer Surendra Sai Institute of Medical Science and Research, Burla, Sambalpur, Odisha, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20204097

Keywords:

Antibiotic resistance, Anatomical therapeutic classification, Defined daily dose, Bed day

Abstract

Background: Antibiotic resistance is a global health problem. Improper use of antibiotics leads to development of antibiotic resistance, side effects, superinfections and increase in treatment costs. There are few publications on antibiotic consumption. Serious morbidity and mortality are associated with postoperative wound infections. The use of peri or pre-operative antibiotics has resulted in a reduced risk of postoperative infection when appropriate principles of prophylaxis are applied.

Methods: An observational study during a 2-month period was carried out in the department of surgery of Veer Surendra Sai Institute of Medical Science and Research, Burla. We utilized the administrative data for expression of antibiotic consumption using anatomical therapeutic classification (ATC) / defined daily dose (DDDs) methodology. The information included were drug names, strength, pharmaceutical form, quantity dispensed, total number of patients admitted during the study period and average length of stay. Each drug was then given a code according to the ATC classification. The number of DDDs and DDDs/100 bed days was calculated.

Results: The most frequent antibiotic used was cephalosporin group with DDDs 62.70 DDDs/100 bed days (44.34%) followed by metronidazole with 23.10 DDDs/100 bed days (16.34%). Among cephalosporin group most common antibiotic used was ceftriaxone with 24.46 DDDs/100 bed days. The mean duration of stay was 7.2 days.

Conclusions: The results of this study are similar to previous studies and it showed that there is irrational use of antibiotics as there is no antibiotic policy in our hospital. Drug utilization research should be carried out at frequent intervals to improve rational use of antibiotics.

Author Biographies

Rashmi R. Pujari, Department of Pharmacology, Veer Surendra Sai Institute of Medical Science and Research, Burla, Sambalpur, Odisha, India

Dept of Pharmacology. Postgraduate student

Bhabagrahi Rath, Department of Pharmacology, Veer Surendra Sai Institute of Medical Science and Research, Burla, Sambalpur, Odisha, India

Dept of Pharmacology. Professor and Head of dept

Tapan Kumar Nayak, Department of Surgery, Veer Surendra Sai Institute of Medical Science and Research, Burla, Sambalpur, Odisha, India

Dept of Surgery. Assistant professor

References

Arda B, Yamazhan T, Sipahi OR, Taşbakan MI, Büke Ç, Ulusoy S. This is a very good idea for the Ege University Faculty of Health Sciences to provide you with the best practice possible. Hastane Infection Dergisi. 2004,8:14-5.

Cizman M: The use and resistance to antibiotics in the community. Int J Antimicrob Agents. 2003,21:297-307.

Haley RW, Schaberg DR, Crossley KB, Von Allmen SD, McGowan JE Jr. Extra charges and prolongation of stay attributable to nosocomial infections: a prospective inter hospital comparison. Am J Med. 1981;70:51-8.

Hosoglu S, Esen S, Ozturk R: The effect of a restriction policy on the antimicrobial consumption in Turkey: a country-wide study. Eur J Clin Pharmacol. 2005,61:727-31.

Esposito S, Leone S. Antimicrobial treatment for intensive care unit (ICU) infections including the role of the infectious diseases specialist. Int J Antimicrob Agents. 2007;29:494-500.

Shankar PR, Upadhyay DK, Subish P, Bhandari RB, Das B. Drug utilisation among older inpatients in a teaching hospital in Western Nepal. Singapore Med J. 2010;51:28-34.

World Health Organization (WHO), Collaborating Centre for Drug Statistics Methodology: Guidelines for ATC classification and DDD assignment 2010. 2009, Available at, http://www.whocc.no/atcddd/. Accessed on 14 June 2019.

Sozen. Application of ATC/DDD methodology to evaluate antibiotic use in a general hospital of Turkey. Annals Clin Microbiology Anti-microbials. 2013;12:13.

Williams A, Mathai AS, Phillips AS. Antibiotic prescription audit in the intensive care unit. J Pharma Bioalli Sci. 2011;3:4.

Gordana Pesic. Application of ATC/DDD methodology to compare antibiotic utilization in two university hospital surgical departments. Med Biology. 2005;12(3):174-8.

Shrikala B, Kranthi K, Nafisa. A prospective study on evaluation of antibiotic prescription practices in an intensive care unit of a tertiary care hospital. J Clin Diag Res. 2010;4:3387-91.

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Published

2020-09-22

How to Cite

Pujari, R. R., Rath, B., & Nayak, T. K. (2020). Measurement of antibiotic consumption in surgical ward of a tertiary care hospital. International Journal of Basic & Clinical Pharmacology, 9(10), 1565–1568. https://doi.org/10.18203/2319-2003.ijbcp20204097

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Section

Original Research Articles