Study on drug utilization pattern and cost analysis among the psychiatric patients treated with various benzodiazepine derivatives

Authors

  • Dhivya Govindasamy Department of Pharmacy, Annamalai University, Annamalai Nagar, Tamil Nadu, India
  • Gandhibabu Ramanathan Department of Psychiatry, Annamalai University, Annamalai Nagar, Tamil Nadu, India
  • Talari Venkata Siva Prasad Department of Pharmacy, Annamalai University, Annamalai Nagar, Tamil Nadu, India
  • Gopalakrishnan Ganesan Department of Pharmacy, Annamalai University, Annamalai Nagar, Tamil Nadu, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20202193

Keywords:

Drug utilization, Benzodiazepine, DDD, Cost analysis

Abstract

Background: The objective of the study was to assess drug utilization pattern and cost analysis among the psychiatric patients treated with various benzodiazepine derivatives.

Methods: This observational study was conducted in department of psychiatric, RMMCH, Annamalai University. The study period was 6 months (November 2018 to April 2019). A total of 50 psychiatric patients were included.

Results: A total 50 patients among them 64% (32) males and 36% (18) female, were included in the study. Most of the patient were between the age groups of 18-29 years (30%). The most common clinical condition treated with benzodiazepines were alcohol dependence syndrome/alcohol withdrawal syndrome/ alcohol related psychotic disorder (34%). The majority of patients were prescribed with clonazepam (66.67%). The defined daily dose (DDD) per 100 bed days of benzodiazepines were found to be 0.89. In this study the comparison of cost analysis for the drug used and it was found that lorazepam (122%) are most expensive followed by chlordiazepoxide (93.3%) and clonazepam (78.57%). The cheapest drug was nitrazepam (36.84%).

Conclusions: The majority of the patient admitted in the psychiatric department were suffering from Alcohol depending syndrome/alcohol withdrawal syndrome. The most commonly prescribed benzodiazepine was clonazepam followed by lorazepam and least prescribed diazepam and nitrazepam based on defined daily dose concept.

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Published

2020-05-21

How to Cite

Govindasamy, D., Ramanathan, G., Siva Prasad, T. V., & Ganesan, G. (2020). Study on drug utilization pattern and cost analysis among the psychiatric patients treated with various benzodiazepine derivatives. International Journal of Basic & Clinical Pharmacology, 9(6), 975–979. https://doi.org/10.18203/2319-2003.ijbcp20202193

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Original Research Articles