New corona virus: is just a tip of iceberg?
Keywords:Antiviral, COVID-19, New corona virus, SARS-CoV-2
The world is again experiencing a global viral epidemic of zoonotic origin. As of March 30, 785807 confirmed cases of coronavirus disease 2019 (COVID-19) and 37820 deaths had been reported in more than 120 countries. Strenuous efforts are being made by various countries of the world to halt transmission through shutting down transport, quarantining entire cities and enforcing the use of face masks. International flights have been cancelled and affected cruise ships quarantined. As in all outbreaks, there is an urgent need to develop effective diagnostics, therapeutics and vaccines. Several experimental diagnostic platforms are already in use in China and elsewhere. The whole-genome sequence of SARS-CoV-2 has been obtained and shared widely. Several potential treatments have been proposed, however, no antiviral treatment has been approved for the novel coronavirus, and despite two outbreaks of novel coronaviruses in the past two decades, vaccine development is still in its infancy.
Stohlman SA, Hinton DR. Viral induced demyelination. Brain Pathol. 2001;1:92-106.
Jubelt B, Berger JR. Does viral disease underlie ALS? Lessons from the AIDS pandemic. Neurol. 2001;57(6):945-6.
Shingadia D, Bose A, Booy R. Could a herpesvirus be the cause of Kawasaki disease? Lancet Infect Dis. 2002;2(5):310-3.
Tyrrel DAJ, Almedia JD, Berry DM, Cunningham CH, Hamre D, Hofstad MS, et al. Coronavirus. Nature. 1968;220:650.
Peiris JSM, Coronaviruses. In: Douglas DR, Richard JW, Frederick GH, editors. Clincal Virology. 4th ed. Washington DC: ASM Press; 2017:587-593.
Holmes KV, Lai MMC. Coronaviridae. In: Fields BN, editor. Fields Virology. 3rd ed. Philadelphia: Lippincott-Raven Publishers; 1995:1075-1093.
Guy JS, Breslin JJ, Breuhaus B, Vivrette S, Smith LG. Characterization of a coronavirus isolated from a diarrheic foal. J Clin Microbiol. 2000;38(12):4523-6.
Peiris JS, Chu CM, Cheng VC, Chan KS, Hung IF, Poon LL, et al. Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study. Lancet. 2003;361(9371):1767-72.
Martina BE, Haagmans BL, Kuiken T, Fouchier RA, Rimmelzwaan GF, Van Amerongen G, et al. Virology: SARS virus infection of cats and ferrets. Nature. 2003;425(6961):915.
Guan Y, Zheng BJ, He YQ, Liu XL, Zhuang ZX, Cheung CL, et al. Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China. Sci. 2003;302(5643):276-8.
World Health Organization. Director-General's remarks at the media briefing on 2019-nCoV. 2020. Available at: https://www.who.int/dg/speeches/ detail/who-director-general-s-remarks-at-the-media-briefing-on-2019-ncov-on-11-february-2020. Accessed on 15th February 2020.
World Health Organization. Novel coronavirus situation report-2, 2020. Available at: https://www. who.int/docs/default-source/corona viruse/situation-reports/20200122-sitrep-2-2019-ncov.pdf. Accessed on 23rd January 2020.
British broadcasting corporation. Coronavirus: Newborn becomes youngest person diagnosed with virus, 2020. Available at: https://www.bbc.com/ news/world-asia-china-51395655. Accessed on 7th February 2020.
New York post. Second newborn baby tests positive for coronavirus, 2020. Available at: https://nypost. com/2020/03/13/second-newborn-baby-tests-positive-for-coronavirus/. Accessed on 15th March 2020.
Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, et al. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med. 2020;382(13):1199-207.
Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382(18):1708-20.
World Health Organization. Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19), 2020. Available at: https://www.who. int/docs/default-source/corona viruse/who-china-joint-mission-on-covid-19-final-report.pdf. Accessed on 15th March 2020.
Bouadma L, Lescure FX, Lucet JC, Yazdanpanah Y, Timsit JF. Severe SARS-CoV-2 infections: practical considerations and management strategy for intensivists. Intensive Care Med. 2020;46(4):579-82.