Evaluation of anti-asthmatic and anti-cholinergic activity of ethanolic extract of Tectina grandis Linn. bark

Authors

  • Deepali J. Jaybhaye Department of Pharmacology, Mahatma Gandhi Mission Hospital and Medical College, Aurangabad, Maharashtra, India
  • Prashant S. Chaudhary Department of Pharmacology, Mahatma Gandhi Mission Hospital and Medical College, Aurangabad, Maharashtra, India
  • Shruti Chandra Department of Pharmacology, Mahatma Gandhi Mission Hospital and Medical College, Aurangabad, Maharashtra, India
  • Sukhmeen Johar Department of Pharmacology, Mahatma Gandhi Mission Hospital and Medical College, Aurangabad, Maharashtra, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20201179

Keywords:

Anti-asthmatic, Anti-cholinergic, Tectona grandis Linn. bark extract

Abstract

Background: Asthma is a chronic disease that affects approximately 300 million people worldwide. Tectona grandis Linn. bark, also known as Teak (English), is traditionally used to treat asthma. However, the scientific data on anti-asthmatic and anti-cholinergic of this plant has got little attention. An attempt has been based on ethanolic extract of bark of Tectona grandis Linn. shown a tremendous effect on asthma when comparative study was done with normal and treated group.

Methods: The anti-asthmatic activity of a 95% ethanol and 5% distilled water extract of dried and fresh Tectona grandis Linn. bark, was evaluated against histamine and acetylcholine-induced preconvulsive dyspnea (PCD) in guinea pigs fasted for 24 h were exposed to an atomized fine mist of 2% histamine dihydrochloride and acetylcholine aerosol (dissolved in normal saline) using nebulizer at a pressure of 300 mmHg in the histamine chamber (24×14×24 cm, made of perplex glass. They were divided in groups Mepyramin (8 mg/kg) intraperitonially, atropine aerosol and Tectona grandis bark formulation (2.5, 5, 10 gm/kg) were administered orally 30 min prior to exposure. Animals, which did not develop typical asthma within 6 minutes, were taken as protected.

Results: Ethanolic extract of Tectona grandis Linn. bark at 5 and 10 gm/kg significantly reduce bronchoconstriction as compared to control group along with significant mast cell stabilization activity.

Conclusions: In conclusion, the present study shows that the ethanolic bark extract of Tectona grandis Linn. has potential antiasthamatic and antichlolinergic action in histamine and acetylcholine broncocontraction in guinea pigs.

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Published

2020-03-24

How to Cite

Jaybhaye, D. J., Chaudhary, P. S., Chandra, S., & Johar, S. (2020). Evaluation of anti-asthmatic and anti-cholinergic activity of ethanolic extract of Tectina grandis Linn. bark. International Journal of Basic & Clinical Pharmacology, 9(4), 572–576. https://doi.org/10.18203/2319-2003.ijbcp20201179

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Original Research Articles