Wound healing suppressant effect of vincristine reversed by vitamin A: an experimental study
DOI:
https://doi.org/10.18203/2319-2003.ijbcp20161552Keywords:
Wound healing, Vincristine, Vitamin A, Antineoplastic agentsAbstract
Background: Use of antineoplastic drugs pre and postoperatively have shown to adversely affect the healing of surgical wounds. Vincristine is an antineoplastic drug with a wide range of antitumor activity. Prior studies have demonstrated that vincristine impairs skin wound healing.
Methods: In this study we investigated the effect of vitamin A on vincristine induced suppression of healing in two wound models, viz: incision and dead space in rats. Hydroxyproline (measure of collagen) was estimated colorimetrically and breaking strength of the wound and granulation tissue was measured.
Results: Vincristine (60 mcg/Kg intraperitoneally, on the 3rd wounding day) significantly reduced breaking strength in both incision and dead space wound models. Vitamin A (5000 I.U, Subcutaneously on alternate days) by itself did not alter any of the parameters studied but reversed the suppressant effects of vincristine on wound healing.
Conclusions: Vitamin A by itself produced little effect on healing except a modest increase in granulation mass. But it significantly reversed the healing suppressant effects of vincristine.
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References
Payne WG, Naidu DK, Wheeler CK, Barkoe D, Mentis M, Emerick R. Wound healing in patients with cancer. E Plasty. 2008; 8(9):68-90.
Alagol H, Dinc S, Basgut B, Abacioglu N. Temporal variation in the recovery from impairment in adriamycin-induced wound healing in rats. J Circadian Rhythms. 2007;5:6.
Guo S, DiPietro LA. Factors affecting wound healing. J Dent Res. 2010;89(3):219-29.
Watters CA, Tredget EE. Nutrition and wound healing. The Canadian J CME. 2002:65-74.
Goodman de WS. Vitamin A and retinoids in health and disease. N Eng J Med. 1984;310:1023.
Bellag W. Vitamin A and retinoids from nutrition to pharmacotherapy in dermatology and oncology. Lancet. 1983;1:860-3.
Raju SS, Kulkarni DR. Vitamin A reverse the wound healing suppressant effect of cyclophosphamide. Ind J Pharmac. 1986;18:154-7.
Stratford F, Seifter E, Rettura G, Babyatsky M, Levenson SM. Impaired wound healing due to cyclophosphamide alleviated by supplemental vitamin A. Surg Forum. 1980;31:224-5.
Ehrlich HP, Hunt TK. The effects of cortisone and anabolic steroids on the tensile strength of healing wounds. Ann Surg. 1969;170:203-6.
Lee KH. Studies on mechanism of action of salicylates II. Retardation of wound healing by aspirin. J Pharm Sci. 1968;57:1042-3.
Neuman RE, Logan MA. The determination of hydroxyproline. J Biol Chem. 1950;184:299-306.
Levenson SM, Gruber CA, Rettura G, Gruber DK, Detrione AA, Seifter E. Supplemental vitamin A prevents acute radiation induced defect in wound healing. Ann Surg. 1984; 200(4):494-512.
Mac KJD, Miller LA. Nutritional support for wound healing. Alternative Medicine Review. 2003;8(4):359-77.