Cefixime induce non convulsive status epileptics: a neurotoxic effect

Ankit Bhardwaj; Atma Ram Sharma; Sarla Sharma

doi:10.18203/2319-2003.ijbcp20194284

Authors

Ankit Bhardwaj Department of Neuropsychopharmacology, Institute of Human Behaviour and Allied Sciences, Dilshad Garden, Delhi, India
Atma Ram Sharma Department of Radiology, GTB Hospital and UCMS, Dilshad Garden, Delhi, India
Sarla Sharma Department of Radiology, GTB Hospital and UCMS, Dilshad Garden, Delhi, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20194284

Keywords:

Cephalosporin and seizure, Neurotoxicity and seizure, Antiepileptic drugs

Abstract

Nonconvulsive status epileptics comprises a group of syndromes that display a great diversity regarding response to anticonvulsants ranging from virtually self-limiting variants to entirely refractory forms cephalosporins are thought to provoke seizure through inhibitory effects on gamma-aminobutyric acid (GABA) transmission and GABA receptors. Interference with GABA transmission result in pre-disposition towards excitatory neurotransmission, which can leads to seizures. Antibiotics can alter the serum concentration of anti-epileptic, resulting in seizures and anti-epileptic drugs toxicity.

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