Hyperglycaemia lowering activity and hypoglycaemic risk assessment of Sarenta, an Ivorian traditional herbal remedy

Authors

  • Geneviève A. N’guessan Irié Department of Pharmacology, Felix Houphouet-Boigny University, Abidjan, Côte d’Ivoire http://orcid.org/0000-0002-3414-5991
  • Ange A. Tako Training and Research Unit of Pharmaceutical and Biological Sciences, Felix Houphouet-Boigny University, Abidjan, Côte d’Ivoire
  • Etienne K. Effo Department of Pharmacology, Felix Houphouet-Boigny University, Abidjan, Côte d’Ivoire
  • Landry S. Kouakou Department of Pharmacology, Felix Houphouet-Boigny University, Abidjan, Côte d’Ivoire
  • Gisèle N. Siransy Kouakou Department of Pharmacology, Felix Houphouet-Boigny University, Abidjan, Côte d’Ivoire

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20194103

Keywords:

Plant, Diabetes, Blood glucose

Abstract

Background: Diabetes remains a major public health problem for which traditional medicine is a better therapeutic alternative for low-income populations, including African populations. The aim of this work was to evaluate the effect of Sarenta, an herbal preparation used in Ivorian traditional medicine as anti-diabetic, on hyperglycaemia and on basic glycaemia.

Methods: Hyperglycaemia lowering activity was led in rats receiving glucose at 5 g/kg body weight by gavage after oral pre-treatment with either Sarenta at 125, 206 or 209.5 mg/kg b. wt., either glibenclamide at 10 mg/kg b. wt., or physiological saline solution. Hypoglycaemic risk was assessed by administering the same doses of Sarenta to native i.e. NaCl-treated rats. For both tests, blood glucose was measured before any substance was administered and then every hour for 4 hours.

Results: After 4 hours, Sarenta at 206 mg/kg b. wt. and 209.5 mg/kg b. wt. significantly reduced the induced hyperglycaemia in rats by 33.87% and 37.39%, respectively. The degree of the hyperglycaemia lowering effect of the remedy at these two doses was not significantly different from that of glibenclamide. In addition, Sarenta at 209.5 mg/kg b. wt. resulted in a significant reduction of basic blood sugar to 29.78% four hours after administration.

Conclusions: The remedy Sarenta has a hyperglycaemia lowering activity that could partially justify its traditional use in the treatment of diabetes. However, considering its hypoglycemic effect, precautions should be taken when using this traditional medicine.

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Published

2019-08-28

How to Cite

Irié, G. A. N., Tako, A. A., Effo, E. K., Kouakou, L. S., & Kouakou, G. N. S. (2019). Hyperglycaemia lowering activity and hypoglycaemic risk assessment of Sarenta, an Ivorian traditional herbal remedy. International Journal of Basic & Clinical Pharmacology, 8(9), 1939–1943. https://doi.org/10.18203/2319-2003.ijbcp20194103

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Original Research Articles