Hyperglycaemia lowering activity and hypoglycaemic risk assessment of Sarenta, an Ivorian traditional herbal remedy

Geneviève A. N’guessan Irié, Ange A. Tako, Etienne K. Effo, Landry S. Kouakou, Gisèle N. Siransy Kouakou


Background: Diabetes remains a major public health problem for which traditional medicine is a better therapeutic alternative for low-income populations, including African populations. The aim of this work was to evaluate the effect of Sarenta, an herbal preparation used in Ivorian traditional medicine as anti-diabetic, on hyperglycaemia and on basic glycaemia.

Methods: Hyperglycaemia lowering activity was led in rats receiving glucose at 5 g/kg body weight by gavage after oral pre-treatment with either Sarenta at 125, 206 or 209.5 mg/kg b. wt., either glibenclamide at 10 mg/kg b. wt., or physiological saline solution. Hypoglycaemic risk was assessed by administering the same doses of Sarenta to native i.e. NaCl-treated rats. For both tests, blood glucose was measured before any substance was administered and then every hour for 4 hours.

Results: After 4 hours, Sarenta at 206 mg/kg b. wt. and 209.5 mg/kg b. wt. significantly reduced the induced hyperglycaemia in rats by 33.87% and 37.39%, respectively. The degree of the hyperglycaemia lowering effect of the remedy at these two doses was not significantly different from that of glibenclamide. In addition, Sarenta at 209.5 mg/kg b. wt. resulted in a significant reduction of basic blood sugar to 29.78% four hours after administration.

Conclusions: The remedy Sarenta has a hyperglycaemia lowering activity that could partially justify its traditional use in the treatment of diabetes. However, considering its hypoglycemic effect, precautions should be taken when using this traditional medicine.


Plant, Diabetes, Blood glucose

Full Text:



Besançon S, Sidibé AT, Nientao I. Le diabète au Mali: aspects diététiques. Développement et Santé. 2009;193:38-43.

International Diabetes Federation. IDF Diabetes Atlas, 8th ed. 2017.

International Diabetes Federation. IDF Diabetes Atlas, 6th ed. 2013.

Fagot-Campagna A, Romon I, Fosse S, Roudier C. Prévalence et incidence du diabète, et mortalité liée au diabète en Franc : Synthèse épidémiologique, 2010. Available at: doc_num.php?explnum_id=102. Accessed on 12 March 2019.

World Health Organization. WHO Traditional Medicine Strategy 2002–2005, 2002. Available at: Accessed on 23 January 2019.

World Health Organization. WHO Traditional Medicine Strategy 2014–2023, 2013. Available at: Accessed on 30 January 2019.

Kouakou-Siransy G, Effo KE, Irié-Nguessan G, Koua D. Analgesic efficacy, quality and safety of "Sarenta": An herbal preparation from Ivorian traditional medicine. Int J Pharmacol. 2017;13(3):257-65.

Effo KE, Djadji ATL, N’Guessan BN, Kouakou SL, Anzoua E, Fatto N, et al. Evaluation of the Anti-inflammatory activity and ulcerogenic risk of "Sarenta", an Ivorian herbal preparation. Int J Pharm Pharmacol 2018;2(3):2581-3080.

Kambouche N, Merah B, Derdour A, Bellahouel S, Younos C, Soulimani R. Activité antihyperglycémiante d’un stérol β-sitoglucoside isolé de la plante Anabasis articulata (Forssk) Moq. Phytothérapie. 2011;9(1):2-6.

Puri D. The insulinotropic activity of a Nepalese medicinal plant Biophytum sensitivum: preliminary experimental study. J Ethnopharmacol. 2001;78(1):89-93.

Ouhdouch F, Errajraji A, Diouri A. La phytothérapie dans le traitement du diabète type 2. Diabetes Metab. 2008;34(3):99.

Arya S, Jogender S, Singh S. Antidiabetic activities of Cassia occidentalis. Recent Res Sci Technol. 2013;5(1):51-3.

Gbekley HE, Karou DS, Gnoula C, Agbodeka K, Anani K, Tchacondo T, et al. Étude ethnobotanique des plantes utilisées dans le traitement du diabète dans la médecine traditionnelle de la région maritime du Togo, Pan Afr Med J. 2018;30:186.

Aguiyi J, Obi C, Gang S, Igweh A. Hypoglycaemic activity of Ocimum gratissimum in rats. Fitoterapia. 2000;71(4):444-6.

Maiti R, Jana D, Das U, Ghosh D. Antidiabetic effect of aqueous extract of seed of Tamarindus indica in streptozotocin-induced diabetic rats. J Ethnopharmacol. 2004;92(1):85-91.

Gebreyohannis T, Shibeshi W, Asres K. Effects of Solvent Fractions of Caylusea abyssinica (Fresen) Fisch. & Mey. on blood glucose levels of normoglycemic, glucose loaded and Streptozomicin-induced diabetic rodents. J Nat Remedies. 2014;14:67-75.

Shrayyef M, Gerich J. Normal glucose homeostasis. In: Principle of Diabetes Mellitus. Springer; 2010: 19-35.