Comparative studies on the efficacy of lincomycin and bacitracin for the control of necrotic enteritis in broiler chickens

Authors

  • Ashraf A. Elkomy Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, 13736, Moshtohor, Toukh, Elqaliobiya, Egypt
  • Enas Farag Department of Pharmacology, Animal Health Research Institute (Benha branch), Benha Egypt
  • El Shahat I. El Gharbawy Department of Pharmacology, Animal Health Research Institute (Benha branch), Benha Egypt
  • Mohamed Elbadawy Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, 13736, Moshtohor, Toukh, Elqaliobiya, Egypt

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20192177

Keywords:

Bacitracin, Broiler chickens, Clostridium perfringens, Lincomycin, Necrotic enteritis

Abstract

Background: The present study was conducted to evaluate the efficacy of lincomycin and/or bacitracin for control of experimentally-induced Clostridium perfringens (CP) infection in broiler chickens.

Methods: A total of 100 one-day-old Cobb-mixed chicks were divided into five groups (A, B, C, D and E, each of 20 bird). At the 15th day of age, all birds (except group A) were inoculated orally with CP broth culture (109 CFU/mL). Two days later, drugs were orally administered once daily for five consecutive days as follow; Group A and B were left untreated. Group C, D, and E were treated with lincomycin (0.5 g/l), bacitracin (100 mg/l), lincomycin and bacitracin, respectively. The efficacy of used drugs was estimated based on clinical symptoms, body weight, weight gain, feed conversion rate. Hematobiochemical changes were also determined.

Results: Necrotic enteritis in broiler chickens induced a significant decrease in body weight, weight gain, erythrocytic count, hemoglobin content, PCV %, serum proteins, catalase, and superoxide dismutase. Additionally, a marked decrease in serum lipids was obtained. Furthermore, a significant increase in feed conversion rate, leukocytic count, phagocytic activity, phagocytic index, serum total globulin, γ globulin and malondialdehyde coupled with a marked increase in β and α globulins were determined. Medication of infected broilers with lincomycin and/or bacitracin improved clinical signs and reduced mortality rate to 8, 6 and 2%, respectively, as well as restored the performance and hematobiochemical alterations.

Conclusions: a combination of lincomycin and bacitracin was of considerable value for the control of necrotic enteritis in broiler chickens.

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Published

2019-05-23

How to Cite

Elkomy, A. A., Farag, E., El Gharbawy, E. S. I., & Elbadawy, M. (2019). Comparative studies on the efficacy of lincomycin and bacitracin for the control of necrotic enteritis in broiler chickens. International Journal of Basic & Clinical Pharmacology, 8(6), 1153–1158. https://doi.org/10.18203/2319-2003.ijbcp20192177

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Original Research Articles