Hemodynamic effects of contrast media and its adverse effects in Western Rajasthan: an observational study


  • Akhtar Ali Department of Pharmacology, S.N. Medical College, Jodhpur, Rajasthan, India
  • Rajkumar Rathore Department of Pharmacology, S.N. Medical College, Jodhpur, Rajasthan, India
  • Kirti Chaturvedi Department of Radiology, Dr. S.N. Medical College, Jodhpur, Rajasthan, India
  • Amreesh Parvez Life Sciences and Biotechnology, South Asian University, New Delhi, India




Adverse drug reactions, CT scan, Diatrizoate sodium, Iohexol


Background: This study was aimed to investigate the hemodynamic effects of CT scan contrast media on pulse rate and blood pressure as well as identify the possible adverse drug reactions occurring after administration of contrast media.

Methods: Information of patients such as age, sex, diagnosis, prescribed body part for CT scan, amount of contrast media and route of administration of contrast media were collected. Pulse and blood pressure were measured three times, before administration of iohexol or diatrizoate sodium; after 5 min and 1 hr administration of iohexol; after 1 hr and 2 hr starting of administration of diatrizoate sodium. ADR occurring after contrast media administration were observed.

Results: Before Iohexol administration, SBP was 126.85±18.47 mmHg, which increased by 129.92±20.51 and 128.24±19.89 mmHg after 5 min. and 1 hr respectively after administration. Whereas before iohexol administration, DBP was 81.28±11.5 mm Hg, which was decreased by 80.58±13.03 and 78.90±13.15 mmHg after administration. The p-value for PR, pre-iohexol vs 1 hr post-iohexol was highly significant. Before Diatrizoate Sodium administration, SBP was 128.84±17.64 mmHg, that was decreased with 126.23±17.92 and 124.15±17.04 mmHg after administration. On the other hand, DBP was 81±11.99 mmHg which was decreased with 80.23±11.07 and 79.84±11.31 mmHg by Diatrizoate Sodium administration. P-value for SBP, DBP, and PR in various comparison of diatrizoate sodium administration was insignificant as well as total 18 ADRs were recorded post diatrizoate sodium and iohexol administration.

Conclusions: Present study result demonstrates PR was significantly increased by administration of iohexol but not that much due to Diatrizoate Sodium especially after the 1 hr of iohexol administration. Although DBP decreased by both drugs, on the other hand, SBP increased by iohexol and decreased by Diatrizoate Sodium administration which was clinically insignificant. Although headache and giddiness were most common ADRs by both drugs.


Frush DP. Imaging of pediatric mediastinal masses. Ann Acad Med Singapore. 2003;32:525-35.

Kopka L, Rodenwaldt J, Fischer U, Mueller DW, Oestmann JW, Grabbe E. Dual-phase helical CT of the liver: Effects of bolus tracking and different volumes of contrast material. Radiol. 1996;201:321-6.

Mehnert F, Pereira PL, Trübenbach J, Kopp AF, Claussen CD. Biphasic spiral CT of the liver: Autonomic bolus tracking or time delay? Eur Radiol. 2001;11:427-31.

Widmark JM. Imaging-related medications: A class overview. Pro Baylor Med Cen Pharmacol Notes: Garland. 2007;20:408-17.

Manual on contrast media. 2008. Available at: www.acr.org/Secondary Main Menu Categories / quality_safety/contrast_manual.aspx.

Nguyen SA, Suranyi P, Ravenel JG, Randall PK, Romano PB, Strom KA, et al. Iso-osmolality versus low-osmolality iodinated contrast medium at intravenous contrast-enhanced CT: effect on kidney function. Radiol. 2008;248(1):97-105.

Hsieh YC, Liu TJ, Liang KW, Her HY, Lin WW, Wang KY, et al. Iso-osmolar ccontrast medium better preserves short- and long-term renal function after cardiovascular catheterizations in patients with severe baseline renal insufficiency. Int J Cardiol. 2006;111:182-4.

Barrett BJ, Katzberg RW, Thomsen HS, Chen N, Sahani D, Soulez G, et al. Contrast-induced nephropathy in patients with chronic kidney disease undergoing computed tomography: A double-blind comparison of iodixanol and iopamidol. Invest Radiol. 2006;41:815-21.

Lindholt JS. Radiocontrast induced nephropathy. Eur J Vasc Endovasc Surg. 2003 Apr 1;25(4):296-304.

Romano G, Briguori C, Quintavalle C, Zanca C, Rivera NV, Colombo A, et al. Contrast agents and renal cell apoptosis. Eur Heart. 2008 May 8;29(20):2569-76.

Schild HH, Kuhl CK, Hübner-Steiner U, Böhm I, Speck U. Adverse events after unenhanced and monomeric and dimeric contrast-enhanced CT: a prospective randomized controlled trial. Radiol. 2006 Jul;240(1):56-64.

Wong PC, Li Z, Guo J, Zhang A. Pathophysiology of contrast-induced nephropathy. Int J Cardiol. 2012 Jul 12;158(2):186-92.

Katayama H, Yamaguchi K, Kozuka T, Takashima T, Seez P, Matsuura K. Adverse reactions to ionic and nonionic contrast media. A report from the Japanese Committee on the Safety of Contrast Media. Radiolo. 1990 Jun;175(3):621-8.

Kopp AF, Mortele KJ, Cho YD, Palkowitsch P, Bettmann MA, Claussen CD. Prevalence of acute reactions to iopromide: postmarketing surveillance study of 74,717 patients. Acta Radiol. 2008;49:902-11.

Mortelé KJ, Oliva MR, Ondategui S, Ros PR, Silverman SG. Universal use of nonionic iodinated contrast medium for CT: evaluation of safety in a large urban teaching hospital. Am J Roentgenol. 2005 Jan;184(1):31-4.

Hirshfeld JJ, Wieland JE, Davis CA, Giles BD, Passione DA, Ray MB, et al. Hemodynamic and electrocardiographic effects of ioversol during cardiac angiography. Comparison with iopamidol and diatrizoate. Invest Radiol. 1989;24(2):138-44.

Ning P, Zucker EJ, Wong P, Vasanawala SS. Hemodynamic safety and efficacy of ferumoxytol as an intravenous contrast agents in pediatric patients and young adults. Magnetic Resonance Imaging. 20161;34(2):152-8.

Hayashi T, Saitoh S, Tsuji Y, Takahashi J, Tagaya N, Hiramoto M, et al. Influence of Gadoxetate Disodium on Oxygen Saturation and Heart Rate during Dynamic Contrast-enhanced MR Imaging. Radiol. 2015;276(3):756-65.

James J. Zhang, MD, Joel Morganroth, MD, Barry Hogstrom, MD. Electrocardiographic Response to Intravenous and Intraarterial Injection of Iosimenol (A New, Iodinated, Non-Ionic, Iso-Osmolar Contrast Medium). J Invasive Cardiol. 2016; 25:11.

Subathra A, Sandhiya S, Kesavan R. An analysis of adverse drug reactions to radiographic contrast media reported during a 3 year period in a tertiary care hospital in south India. Indian J Physiol Pharmacol. 2014;58(1):45-50.

Egbert RE, De Cecco CN, Schoepf UJ, McQuiston AD, Meinel FG, Katzberg RW. Delayed adverse reactions to the parenteral administration of iodinated contrast media. Am J Roentgenol. 2014;203(6):1163-70.




How to Cite

Ali, A., Rathore, R., Chaturvedi, K., & Parvez, A. (2019). Hemodynamic effects of contrast media and its adverse effects in Western Rajasthan: an observational study. International Journal of Basic & Clinical Pharmacology, 8(5), 967–972. https://doi.org/10.18203/2319-2003.ijbcp20191585



Original Research Articles