DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20190673

Effect of Amomum subulatum seeds against cypermethrin induced haematological changes in wistar albino rats

Goutham Sagarkatte Puttanna, Purushotham K., Swarnalatha Nayak, Eesha B. Rao, Ravi Mundugaru

Abstract


Background: Cypermethrin is a well know agricultural pesticide used in the developing countries. It is associated with significant toxic potential on human health. Hence the present study was aimed to evaluate the protective role of Amomum subulatum against cypermethrin induced haematalogical changes in Wistar albino rats.

Methods: The albino rats were divided into five different groups of six rats each. Group I considered as normal control, group II cypermethrin control (25mg/kg body weight p.o.), group III only test drug and group IV and V administered with cypermethrin 25mg/kg body weight along test drug 1.08 and 2.16mg/kg body weight for 28 consecutive days. At the end of 28th day blood was withdrawn and total haematalogical parameters were estimated.

Results: In the cypermethrin control there was significant reduction in the WBC, Platelet, MCHC and considerable reduction in the haemoglobulin concentration in comparison to normal control. The test drug administered at both dose levels was significantly reversed the cypermethrin induced changes in haematalogical parameters.

Conclusions: Authors can conclude that the Amomum subulatum has potency to reverse the cypermethrin induced haematalogical changes.


Keywords


Amomum subulatum, Cypermethrin, Haemoglobulin, Platelet

Full Text:

PDF

References


Sharma P, Huq AU, Singh R. Cypermethrin-induced reproductive toxicity in the rat is prevented by resveratrol. J Hum Reprod Sci. 2014 Apr;7(2):99.

Srinivas Rao CH, Venkateswarlu V, Surender T, Eddleston M, Buckley NA. Pesticide poisoning in south India: opportunities for prevention and improved medical management. Trop Med Int Health. 2005 Jun;10(6):581-8.

Aktar W, Sengupta D, Chowdhury A. Impact of pesticides use in agriculture: their benefits and hazards. Interdisciplinary Toxicol. 2009 Mar 1;2(1):1-2.

Ahme AM, Naqvi SNH, Akhtar K, Moinuddin, Parveen S. Effect of pesticide residues on health and blood parameters of farm workers from rural Gadap. J Environment Biol. 2009;30(5):747-56.

Sharma E, Sharma R, Singh KK, Sharma G. A boon for mountain populations: Large cardamom farming in the Sikkim Himalaya. Mountain Res Developent. 2000 May;20(2):108-11.

Gupta PN. Studies on capsule morphology of large cardamom cultivars (Amomum subulatum Roxb), J. Plantation Crops. 1986;16:371-5.

Shukla SH, Mistry HA, Patel VG, Jogi BV. Pharmacognostical, preliminary phytochemical studies and analgesic activity of Amomum subulatum Roxb. Pharma Sci Monitor. 2010;1(1):90-102.

Jafri MA, Javed K, Singh S. Evaluation of the gastric antiulcerogenic effect of large cardamom (fruits of Amomum subulatum Roxb). J Ethnopharmacol. 2001 May 1;75(2-3):89-94.

Verma SK, Rajeevan V, Bordia A, Jain V. Greater cardamom (Amomum subulatum Roxb.): A cardio-adaptogen against physical stress. J Herb Med Toxicol. 2010;4(2):55-8.

Vavaiya RB, Patel A, Manek RA. Anti-diabetic activity of Amomum subulatum Roxb. fruit constituents. IJPI. 2010;2(5):50-63.

Bhatti GK, Sidhu IP, Saini NK, Puar SK, Singh G, Bhatti JS. Ameliorative role of melatonin against cypermethrin induced hepatotoxicity and impaired antioxidant defense system in Wistar rats. IOSR J Environment Sci Toxicol Food Technol. 2014 Feb;8(1):39-48.

Chatterjee A, Pakrashi SC. Treaties on Indian medicinal plants: National Institute of Science Communication and information resources, New Delhi, India. 2003;3:146-7,149.

Paget GE, Barnes JM. Evaluation of drug activities. In: Lawrence DR, Bacharach AL, editors. Pharmacometrics. New York; Academic press 161;1964.

Adjrah Y, Karou SD, Agbonon A, Ameyapoh Y, Gbeassor M. Effect of cypermethrin-treated lettuce (Lactuca sativa) on wistar rat liver. J App Pharmaceut Sci. 2013 Jan 1;3(1):128.

Buckley CD, Barone F, Nayar S, Benezech C, Caamano J. Stromal cells in chronic inflammation and tertiary lymphoid organ formation. Ann Rev Immunol. 2015 Mar 21;33:715-45.

Nair H, Nokes DJ, Gessner BD, Dherani M, Madhi SA, Singleton RJ, et al. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet. 2010 May 1;375(9725):1545-55.