Screening of liver protective effect of ethanolic leaf extract of Callicarpa lanata (EECL) in ethanol induced hepatotoxicity in wister rats

Authors

  • Zulfkar Latief Qadrie Department of Pharmacology and Toxicology, Pratishta Institute of Pharmaceuticals Sciences, Suryapet, Hyderabad, Telangana, India
  • Rajkapoor Balasubramanium Department of Pharmacology, Faculty of Medicine, Sebha University, Sebha, Libya
  • Shakil U. Rehman Department of Pharmacology, Govt. Medical College, Baramulla, Jammu and Kashmir, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20190671

Keywords:

Callicarpa lanata, Ethanol, Hepatotoxicity, Hepatocytes, Silymarin

Abstract

Background: The ethanolic extract of Callicarpa lanata (EECL), belonging to the family Verbenaceae, were studied for hepatoprotective activity in Wister rats with liver damage induced by ethanol.

Methods: Ethanol treated rats showed significant increase in the levels of serum enzyme activities, total bilirubin and reduction in total proteins reflecting the liver injury caused by ethanol. EECL, at a dose of 400 and 200mg/kg body weight exhibited hepatoprotective effect by lowering the Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum Alkaline Phosphate (SALP), Gama Glutamyl Transpeptidase (GGTP), total Bilirubin to a significant extent and also significantly increased the levels of total protein in a dose dependent manner.

Results: The results were highly significant at dose level of 400mg/kg body weight (p <0.01) and significant at dose level of 200mg/kg body weight (p <0.05). The effects of EECL at both levels were comparable with standard drug silymarin. The hepatoprotective activity was also supported by histopathological studies of liver tissue.

Conclusions: In-vivo hepatoprotective activity of ethanolic leaf extract of Callicarpa lanata (EECL) against Ethanol induced acute liver injury in rats showed significant results in a dose dependent manner.

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Published

2019-02-23

How to Cite

Qadrie, Z. L., Balasubramanium, R., & Rehman, S. U. (2019). Screening of liver protective effect of ethanolic leaf extract of Callicarpa lanata (EECL) in ethanol induced hepatotoxicity in wister rats. International Journal of Basic & Clinical Pharmacology, 8(3), 595–600. https://doi.org/10.18203/2319-2003.ijbcp20190671

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