Antiproliferative effects of Vanilla planifolia leaf extract against breast cancer MCF-7 cells


  • Vijaybabu Kaliappan Department of Pharmacology, Annapoorna Medical College, Salem, Tamil Nadu, India
  • Punnagai Kumaravelu Department of Pharmacology, Sri Ramachandra Medical College & Research Institute SRIHER, Chennai, Tamil Nadu, India



Breast cancer, DNA fragmentation, IC50, MTT, Phytochemicals


Background: Breast cancer is the most common cancer disease among females in India and worldwide. This needs a critical research for finding the drugs to treat breast cancer with less side effects. The aim of the present study is to reveal the anti-proliferative effects of vanilla extract against MCF-7 cells.

Methods: To reveal anti proliferative effects of vanilla leaf extract, MTT assay, cell cycle analysis and DNA fragmentation assay was performed as per standard protocols.

Results: MTT assay showed decrease in cell viability with increase of dose of extract and revealed IC50 value at 31.2µg/ml. DNA fragmentation was seen in extract treated cells.

Conclusions: The results of the present study confirm the antiproliferative property of vanilla leaf extract in MCF-7 cells. This study results conclude vanilla leaf extract as an effective plant source medicament for treating breast cancer.


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How to Cite

Kaliappan, V., & Kumaravelu, P. (2018). Antiproliferative effects of Vanilla planifolia leaf extract against breast cancer MCF-7 cells. International Journal of Basic & Clinical Pharmacology, 8(1), 51–55.



Original Research Articles